Browsing by Author "Fletcher, Steven"
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Item Structural Modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that Improve Selectivity for the Inhibition of Melanoma Cells Containing Active ERK Signaling(Royal Society of Chemistry, 2013) Jung, Kwan-Young; Samadani, Ramin; Chauhan, Jay; Nevels, Kerrick; Yap, Jeremy L.; Zhang, Jun; Worlikar, Shilpa; Lanning, Maryanna E.; Chen, Lijia; Ensey, Mary; Shukla, Sagar; Salmo, Rosene; Heinzl, Geoffrey; Gordon, Caryn; Dukes, Troy; MacKerell, Alexander D., Jr.; Shapiro, Paul; Fletcher, Steven; Pharmacology and Toxicology, School of MedicineWe herein report on the pharmacophore determination of the ERK docking domain inhibitor (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione, which has led to the discovery of compounds with greater selectivities for inhibiting the proliferation of melanoma cells containing active ERK signaling.