Browsing by Author "Fleischer, Candace C."

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    Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults
    (Elsevier, 2022) Hone-Blanchet, Antoine; Bohsali, Anastasia; Krishnamurthy, Lisa C.; Shahid, Salman; Lin, Qixiang; Zhao, Liping; Loring, David; Goldstein, Felicia; John, Samantha E.; Fleischer, Candace C.; Levey, Allan; Lah, James; Qiu, Deqiang; Crosson, Bruce; Radiology and Imaging Sciences, School of Medicine
    Elevated expression of β-amyloid (Aβ1-42) and tau are considered risk-factors for Alzheimer's disease in healthy older adults. We investigated the effect of aging and cerebrospinal fluid levels of Aβ1-42 and tau on 1) frontal metabolites measured with proton magnetic resonance spectroscopy (MRS) and 2) cognition in cognitively normal older adults (n = 144; age range 50-85). Levels of frontal gamma aminobutyric acid (GABA+) and myo-inositol relative to creatine (mI/tCr) were predicted by age. Levels of GABA+ predicted cognitive performance better than mI/tCr. Additionally, we found that frontal levels of n-acetylaspartate relative to creatine (tNAA/tCr) were predicted by levels of t-tau. In cognitively normal older adults, levels of frontal GABA+ and mI/tCr are predicted by aging, with levels of GABA+ decreasing with age and the opposite for mI/tCr. These results suggest that age- and biomarker-related changes in brain metabolites are not only located in the posterior cortex as suggested by previous studies and further demonstrate that MRS is a viable tool in the study of aging and biomarkers associated with pathological aging and Alzheimer's disease.