Browsing by Author "Fjaeldstad, Alexander W."

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    Systemic corticosteroids in coronavirus disease 2019 (COVID‐19)‐related smell dysfunction: an international view
    (Wiley, 2021) Huart, Caroline; Philpott, Carl M.; Altundag, Aytug; Fjaeldstad, Alexander W.; Frasnelli, Johannes; Gane, Simon; Hsieh, Julien W.; Holbrook, Eric H.; Konstantinidis, Iordanis; Landis, Basile N.; Macchi, Alberto; Mueller, Christian A.; Negoias, Simona; Pinto, Jayant M.; Poletti, Sophia C.; Ramakrishnan, Vijay R.; Rombaux, Philippe; Vodicka, Jan; Welge-Lüessen, Antje; Whitcroft, Katherine L.; Hummel, Thomas; Otolaryngology -- Head and Neck Surgery, School of Medicine
    The frequent association between coronavirus disease 2019 (COVID-19) and olfactory dysfunction is creating an unprecedented demand for a treatment of the olfactory loss. Systemic corticosteroids have been considered as a therapeutic option. However, based on current literature, we call for caution using these treatments in early COVID-19-related olfactory dysfunction because: (1) evidence supporting their usefulness is weak; (2) the rate of spontaneous recovery of COVID-19-related olfactory dysfunction is high; and (3) corticosteroids have well-known potential adverse effects. We encourage randomized placebo-controlled trials investigating the efficacy of systemic steroids in this indication and strongly emphasize to initially consider smell training, which is supported by a robust evidence base and has no known side effects.