Browsing by Author "El-Rahyel, Ahmed"

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    Adverse events and residual lesion rate after cold endoscopic mucosal resection of serrated lesions ≥10 mm
    (Elsevier, 2020) McWhinney, Connor D.; Vemulapalli, Krishna C.; El-Rahyel, Ahmed; Abdullah, Noor; Rex, Douglas K.; Medicine, School of Medicine
    Background and Aims Cold endoscopic mucosal resection (EMR) is being increasingly used for large serrated lesions. We sought to measure residual lesion rates and adverse events after cold EMR of large serrated lesions. Methods In a single academic center, we retrospectively examined a database of serrated class lesions ≥ 10 mm removed with cold EMR for safety and efficacy. Results Five hundred and sixty-six serrated lesions ≥10 mm in size were removed from 312 patients. We successfully contacted 223 patients (71.5%) with no reported serious adverse events that required hospitalization, repeat endoscopy, or transfusion. The residual lesion rate per lesion at first follow-up colonoscopy was 18 out of 225 (8%; 95% CI, 5-12.1). Lesions with residual were larger at polypectomy compared with lesions without recurrence (median, 23 mm vs 16 mm, p=0.017). Conclusion Cold EMR appears to be safe and effective for the removal of large serrated lesions.
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    Impact of changing diagnostic criteria on the diagnosis of serrated polyposis syndrome
    (Thieme, 2023-01-04) McWhinney, Connor D.; Lahr, Rachel E.; Lee, Christopher J.; El-Rahyel, Ahmed; Rex, Douglas K.; Medicine, School of Medicine
    Background and study aims: The World Health Organization criteria for serrated polyposis syndrome (SPS) were established in 2010 and modified in 2019. Neither set of criteria have been validated against genetic markers or proven to be the optimal criteria for defining colorectal cancer risk in patients with serrated colorectal lesions. In this study, we sought to gain insight into how frequently the change in SPS criteria in 2019 impacted the diagnosis of SPS. Patients and methods: We reviewed 279 patients with SPS diagnosed between 2010 and 2019 using the 2010 criteria (n = 163) or since 2019 using the 2019 criteria (n = 116). We reviewed whether patients in each group met the diagnosis of SPS by the alternative criteria. Results: Of those diagnosed using 2010 criteria, 5.5 % did not meet 2019 criteria. Of those diagnosed by 2019 criteria, 10.3 % did not meet 2010 criteria. Conclusions: Most patients with SPS in our database met the diagnosis of SPS by both 2010 and 2019 criteria, with only 5 % to 10 % of patients in each cohort not meeting the alternative diagnostic criteria.