Browsing by Author "Dela Cruz, Charles S."

Now showing 1 - 9 of 9
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    Adenovirus Infection and Outbreaks: What You Need to Know
    (ATS, 2019) Dela Cruz, Charles S.; Pasnick, Susan; Gross, Jane E.; Keller, Jon; Carlos, W. Graham; Cao, Bin; Jamil, Shazia; Medicine, School of Medicine
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    ATS Health Alert—Vaping-associated Pulmonary Illness (VAPI)
    (ATS, 2019) Carlos, W. Graham; Crotty Alexander, Laura E.; Gross, Jane E.; Dela Cruz, Charles S.; Keller, Jonathan M.; Pasnick, Susan; Jamil, Shazia; Medicine, School of Medicine
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    COVID-19 Disease due to SARS-CoV-2 (Novel Coronavirus)
    (ATS, 2020) Carlos, W. Graham; Dela Cruz, Charles S.; Cao, Bin; Pasnick, Susan; Jamil, Shazia; Medicine, School of Medicine
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    COVID-19: How Do We Stay Safe?
    (American Thoracic Society, 2020-07-10) Carlos, W. Graham; Dela Cruz, Charles S.; Cao, Bin; Gross, Jane E.; Pasnick, Susan; Jamil, Shazia; Medicine, School of Medicine
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    Diagnosis and Management of COVID-19 Disease
    (American Thoracic Society, 2020) Jamil, Shazia; Mark, Nick; Carlos, Graham; Dela Cruz, Charles S.; Gross, Jane E.; Pasnick, Susan; Medicine, School of Medicine
    SARS-CoV-2 is a novel coronavirus that was identified in late 2019 as the causative agent of COVID-19 (aka coronavirus disease 2019). On March 11, 2020, the World Health Organization (WHO) declared the world-wide outbreak of COVID-19 a pandemic. This document summarizes the most recent knowledge regarding the biology, epidemiology, diagnosis, and management of COVID-19.
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    Implementation of a Professional Society Core Curriculum and Integrated Maintenance of Certification Program
    (ATS, 2017) Carlos, W. Graham; Poston, Jason T.; Michaud, Gaetane C.; Dela Cruz, Charles S.; Luks, Andrew M.; Boyer, Debra; Moore, Paul E.; McSparron, Jakob I.; Hayes, Margaret M.; Balachandran, Jay S.; Wang, Tisha S.; Larsson, Eileen; Siegel-Gasiewski, Jennifer; Kantz, Alan; Beck, James M.; Thomson, Carey C.; Department of Medicine, IU School of Medicine
    Medical professional societies exist to foster collaboration, guide career development, and provide continuing medical education opportunities. Maintenance of certification is a process by which physicians complete formal educational activities approved by certifying organizations. The American Thoracic Society (ATS) established an innovative maintenance of certification program in 2012 as a means to formalize and expand continuing medical education offerings. This program is unique as it includes explicit opportunities for collaboration and career development in addition to providing continuing medical education and maintenance of certification credit to society members. In describing the development of this program referred to as the “Core Curriculum,” the authors highlight the ATS process for content design, stages of curriculum development, and outcomes data with an eye toward assisting other societies that seek to program similar content. The curriculum development process described is generalizable and positively influences individual practitioners and professional societies in general, and as a result, provides a useful model for other professional societies to follow.
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    Measles
    (ATS, 2019) Keller, Jonathan M.; Dela Cruz, Charles S.; Pasnick, Susan; Gross, Jane E.; Carlos, W. Graham; Maves, Ryan; Jamil, Shazia; Medicine, School of Medicine
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    Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis
    (American Association for the Advancement of Science, 2018-05-01) Sisti, Flavia; Wang, Soujuan; Brandt, Stephanie L.; Glosson-Byers, Nicole; Mayo, Lindsey; Son, Young min; Sturgeon, Sarah; Filgueiras, Luciano; Jancar, Sonia; Wong, Hector; Dela Cruz, Charles S.; Andrews, Nathaniel; Alves-Filho, Jose Carlos; Cunha, Fernando Q.; Serezani, C. Henrique; Microbiology and Immunology, School of Medicine
    Sepsis-induced organ damage is caused by systemic inflammatory response syndrome (SIRS), which results in substantial comorbidities. Therefore, it is of medical importance to identify molecular brakes that can be exploited to dampen inflammation and prevent the development of SIRS. We investigated the role of phosphatase and tensin homolog (PTEN) in suppressing SIRS, increasing microbial clearance, and preventing lung damage. Septic patients and mice with sepsis exhibited increased PTEN expression in leukocytes. Myeloid-specific Pten deletion in an animal model of sepsis increased bacterial loads and cytokine production, which depended on enhanced myeloid differentiation primary response gene 88 (MyD88) abundance and resulted in mortality. PTEN-mediated induction of the microRNAs (miRNAs) miR125b and miR203b reduced the abundance of MyD88. Loss- and gain-of-function assays demonstrated that PTEN induced miRNA production by associating with and facilitating the nuclear localization of Drosha-Dgcr8, part of the miRNA-processing complex. Reconstitution of PTEN-deficient mouse embryonic fibroblasts with a mutant form of PTEN that does not localize to the nucleus resulted in retention of Drosha-Dgcr8 in the cytoplasm and impaired production of mature miRNAs. Thus, we identified a regulatory pathway involving nuclear PTEN-mediated miRNA generation that limits the production of MyD88 and thereby limits sepsis-associated mortality.
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    Vaping-associated Pulmonary Illness (VAPI)
    (ATS, 2019) Carlos, W. Graham; Crotty Alexander, Laura E.; Gross, Jane E.; Dela Cruz, Charles S.; Keller, Jonathan M.; Pasnick, Susan; Jamil, Shazia; Medicine, School of Medicine