Browsing by Author "Das, Sandhitsu R."

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    Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease
    (Springer Nature, 2022-03-21) Duong, Michael Tran; Das, Sandhitsu R.; Lyu, Xueying; Xie, Long; Richardson, Hayley; Xie, Sharon X.; Yushkevich, Paul A.; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Wolk, David A.; Nasrallah, Ilya M.; Radiology and Imaging Sciences, School of Medicine
    Alzheimer’s disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in 18F-flortaucipir vs. 18F-fluorodeoxyglucose positron emission tomography as markers of T and neuronal hypometabolism (NM) in 289 symptomatic patients from the Alzheimer’s Disease Neuroimaging Initiative. We identified six T/NM clusters with differing limbic and cortical patterns. The canonical group was defined as the T/NM pattern with lowest regression residuals. Groups resilient to T had less hypometabolism than expected relative to T and displayed better cognition than the canonical group. Groups susceptible to T had more hypometabolism than expected given T and exhibited worse cognitive decline, with imaging and clinical measures concordant with non-AD copathologies. Together, T/NM mismatch reveals distinct imaging signatures with pathobiological and prognostic implications for AD.