Browsing by Author "Clegg, Deborah J."

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    Female Sex and Gender in Lung/Sleep Health and Disease. Increased Understanding of Basic Biological, Pathophysiological, and Behavioral Mechanisms Leading to Better Health for Female Patients with Lung Disease
    (American Thoracic Society, 2018-10-01) Han, MeiLan K.; Arteaga-Solis, Emilio; Blenis, John; Bourjeily, Ghada; Clegg, Deborah J.; DeMeo, Dawn; Duffy, Jeanne; Gaston, Ben; Heller, Nicola M.; Hemnes, Anna; Henske, Elizabeth Petri; Jain, Raksha; Lahm, Tim; Lancaster, Lisa H.; Lee, Joyce; Legato, Marianne J.; McKee, Sherry; Mehra, Reena; Morris, Alison; Prakash, Y. S.; Stampfli, Martin R.; Gopal-Srivastava, Rashmi; Laposky, Aaron D.; Punturieri, Antonello; Reineck, Lora; Tigno, Xenia; Clayton, Janine; Medicine, School of Medicine
    Female sex/gender is an undercharacterized variable in studies related to lung development and disease. Notwithstanding, many aspects of lung and sleep biology and pathobiology are impacted by female sex and female reproductive transitions. These may manifest as differential gene expression or peculiar organ development. Some conditions are more prevalent in women, such as asthma and insomnia, or, in the case of lymphangioleiomyomatosis, are seen almost exclusively in women. In other diseases, presentation differs, such as the higher frequency of exacerbations experienced by women with chronic obstructive pulmonary disease or greater cardiac morbidity among women with sleep-disordered breathing. Recent advances in -omics and behavioral science provide an opportunity to specifically address sex-based differences and explore research needs and opportunities that will elucidate biochemical pathways, thus enabling more targeted/personalized therapies. To explore the status of and opportunities for research in this area, the NHLBI, in partnership with the NIH Office of Research on Women's Health and the Office of Rare Diseases Research, convened a workshop of investigators in Bethesda, Maryland on September 18 and 19, 2017. At the workshop, the participants reviewed the current understanding of the biological, behavioral, and clinical implications of female sex and gender on lung and sleep health and disease, and formulated recommendations that address research gaps, with a view to achieving better health outcomes through more precise management of female patients with nonneoplastic lung disease. This report summarizes those discussions.
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    New Insights Into Dietary Approaches to Potassium Management in Chronic Kidney Disease
    (Elsevier, 2023) Sumida, Keiichi; Biruete, Annabel; Kistler, Brandon M.; Khor, Ban-Hock; Ebrahim, Zarina; Giannini, Rossella; Sussman-Dabach, Elizabeth J.; Avesani, Carla Maria; Chan, Maria; Lambert, Kelly; Wang, Angela Yee-Moon; Clegg, Deborah J.; Burrowes, Jerrilynn D.; Palmer, Biff F.; Carrero, Juan-Jesus; Kovesdy, Csaba P.; Nutrition and Dietetics, School of Health and Human Sciences
    Potassium disorders are one of the most common electrolyte abnormalities in patients with chronic kidney disease (CKD), contributing to poor clinical outcomes. Maintaining serum potassium levels within the physiologically normal range is critically important in these patients. Dietary potassium restriction has long been considered a core strategy for the management of chronic hyperkalemia in patients with CKD. However, this has been challenged by recent evidence suggesting a paradigm shift toward fostering more liberalized, plant-based dietary patterns. The advent of novel potassium binders and an improved understanding of gastrointestinal processes involved in potassium homeostasis (e.g., gastrointestinal potassium wasting) may facilitate a paradigm shift and incorporation of heart-healthy potassium-enriched food sources. Nevertheless, uncertainty regarding the risk-benefit of plant-based diets in the context of potassium management in CKD remains, requiring well-designed clinical trials to determine the efficacy of dietary potassium manipulation toward improvement of clinical outcomes in patients with CKD.
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    Plant-Based Diets in CKD
    (American Society of Nephrology, 2019-01-07) Clegg, Deborah J.; Gallant, Kathleen M. Hill; Medicine, School of Medicine