Browsing by Author "Chen, Yolande"

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    Systems biology of platelet-vessel wall interactions
    (Springer, 2014) Chen, Yolande; Corey, Seth Joel; Kim, Oleg V.; Alber, Mark S.; Department of Medicine, IU School of Medicine
    Platelets are small, anucleated cells that participate in primary hemostasis by forming a hemostatic plug at the site of a blood vessel's breach, preventing blood loss. However, hemostatic events can lead to excessive thrombosis, resulting in life-threatening strokes, emboli, or infarction. Development of multi-scale models coupling processes at several scales and running predictive model simulations on powerful computer clusters can help interdisciplinary groups of researchers to suggest and test new patient-specific treatment strategies.