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Item COVID-19 Infection and Guillain-Barre Syndrome: A Case Series(Cureus, 2022-02-07) Carpenter, Kendal; Iqbal, Ayman; Singh, Romil; Deepika, Keerti; Koritala, Thoyaja; Jain, Nitesh; Alur, Ram Sanjeev; Adhikari, Ramesh; Mellekate, Vishwas S.; Neurology, School of MedicineThe coronavirus disease 2019 (COVID-19) pandemic brought about an unprecedented time. Multiple systemic complications have been recognized with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as it can do much more than affect the respiratory system. One of the intriguing neurological complications is Guillain-Barre syndrome (GBS). We reviewed three cases in which patients presented with GBS following COVID-19 infection. All three cases had positive lumbar puncture results with albumino-cytological dissociation. Each patient was treated with plasmapheresis and improved clinically. Although an exact causal relationship between COVID-19 and GBS cannot be drawn from this case series alone, it signifies the importance of this complication. It warrants further studies to establish the causal relationship. One should have a high suspicion for acute inflammatory demyelinating polyneuropathy (AIDP) in patients presenting with acute onset of ascending weakness following COVID-19 infection.