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Browsing by Author "Berg, Michel J."
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Item Brain-responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas(Wiley, 2017-06) Jobst, Barbara C.; Kapur, Ritu; Barkley, Gregory L.; Bazil, Carl W.; Berg, Michel J.; Bergey, Gregory K.; Boggs, Jane G.; Cash, Sydney S.; Cole, Andrew J.; Duchowny, Michael S.; Duckrow, Robert B.; Edwards, Jonathan C.; Eisenschenk, Stephan; Fessler, A. James; Fountain, Nathan B.; Geller, Eric B.; Goldman, Alica M.; Goodman, Robert R.; Gross, Robert E.; Gwinn, Ryder P.; Heck, Christianne; Herekar, Aamr A.; Hirsch, Lawrence J.; King-Stephens, David; Labar, Douglas R.; Marsh, W. R.; Meador, Kimford J.; Miller, Ian; Mizrahi, Eli M.; Murro, Anthony M.; Nair, Dileep R.; Noe, Katherine H.; Olejniczak, Piotr W.; Park, Yong D.; Rutecki, Paul; Salanova, Vicenta; Sheth, Raj D.; Skidmore, Christopher; Smith, Michael C.; Spencer, David C.; Srinivasan, Shraddha; Tatum, William; Van Ness, Paul; Vossler, David G.; Wharen, Robert E., Jr.; Worrell, Gregory A.; Yoshor, Daniel; Zimmerman, Richard S.; Skarpass, Tara L.; Morrell, Martha J.; Neurology, School of MedicineObjective Evaluate the seizure-reduction response and safety of brain-responsive stimulation in adults with medically intractable partial-onset seizures of neocortical origin. Methods Patients with partial seizures of neocortical origin were identified from prospective clinical trials of a brain-responsive neurostimulator (RNS System, NeuroPace). The seizure reduction over years 2–6 postimplantation was calculated by assessing the seizure frequency compared to a preimplantation baseline. Safety was assessed based on reported adverse events. Additional analyses considered safety and seizure reduction according to lobe and functional area (e.g., eloquent cortex) of seizure onset. Results There were 126 patients with seizures of neocortical onset. The average follow-up was 6.1 implant years. The median percent seizure reduction was 70% in patients with frontal and parietal seizure onsets, 58% in those with temporal neocortical onsets, and 51% in those with multilobar onsets (last observation carried forward [LOCF] analysis). Twenty-six percent of patients experienced at least one seizure-free period of 6 months or longer and 14% experienced at least one seizure-free period of 1 year or longer. Patients with lesions on magnetic resonance imaging (MRI; 77% reduction, LOCF) and those with normal MRI findings (45% reduction, LOCF) benefitted, although the treatment response was more robust in patients with an MRI lesion (p = 0.02, generalized estimating equation [GEE]). There were no differences in the seizure reduction in patients with and without prior epilepsy surgery or vagus nerve stimulation. Stimulation parameters used for treatment did not cause acute or chronic neurologic deficits, even in eloquent cortical areas. The rates of infection (0.017 per patient implant year) and perioperative hemorrhage (0.8%) were not greater than with other neurostimulation devices. Significance Brain-responsive stimulation represents a safe and effective treatment option for patients with medically intractable epilepsy, including adults with seizures of neocortical onset, and those with onsets from eloquent cortex.Item Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography(Wiley Blackwell (Blackwell Publishing), 2015-06) King-Stephens, David; Mirro, Emily; Weber, Peter B.; Laxer, Kenneth D.; Van Ness, Paul C.; Salanova, Vicenta; Spencer, David C.; Heck, Christianne N.; Goldman, Alica; Jobst, Barbara; Shields, Donald C.; Bergey, Gregory K.; Eisenschenk, Stephan; Worrell, Gregory A.; Rossi, Marvin A.; Gross, Robert E.; Cole, Andrew J.; Sperling, Michael R.; Nair, Dileep R.; Gwinn, Ryder P.; Park, Yong D.; Rutecki, Paul A.; Fountain, Nathan B.; Wharen, Robert E.; Hirsch, Lawrence J.; Miller, Ian O.; Barkley, Gregory L.; Edwards, Jonathan C.; Geller, Eric B.; Berg, Michel J.; Sadler, Toni L.; Sun, Felice T.; Morrell, Martha J.; Department of Neurology, IU School of MedicineOBJECTIVE: Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video-electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and lateralize the seizure focus or foci. Chronic ambulatory electrocorticography (ECoG) in patients with MTL epilepsy may provide additional information about seizure lateralization. This analysis describes data obtained from chronic ambulatory ECoG in patients with suspected bilateral MTL epilepsy in order to assess the time required to determine the seizure lateralization and whether this information could influence treatment decisions. METHODS: Ambulatory ECoG was reviewed in patients with suspected bilateral MTL epilepsy who were among a larger cohort with intractable epilepsy participating in a randomized controlled trial of responsive neurostimulation. Subjects were implanted with bilateral MTL leads and a cranially implanted neurostimulator programmed to detect abnormal interictal and ictal ECoG activity. ECoG data stored by the neurostimulator were reviewed to determine the lateralization of electrographic seizures and the interval of time until independent bilateral MTL electrographic seizures were recorded. RESULTS: Eighty-two subjects were implanted with bilateral MTL leads and followed for 4.7 years on average (median 4.9 years). Independent bilateral MTL electrographic seizures were recorded in 84%. The average time to record bilateral electrographic seizures in the ambulatory setting was 41.6 days (median 13 days, range 0-376 days). Sixteen percent had only unilateral electrographic seizures after an average of 4.6 years of recording. SIGNIFICANCE: About one third of the subjects implanted with bilateral MTL electrodes required >1 month of chronic ambulatory ECoG before the first contralateral MTL electrographic seizure was recorded. Some patients with suspected bilateral MTL seizures had only unilateral electrographic seizures. Chronic ambulatory ECoG in patients with suspected bilateral MTL seizures provides data in a naturalistic setting, may complement data from inpatient video-EEG monitoring, and can contribute to treatment decisions.