Browsing by Author "Alterovitz, Wei-Lun"

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    AI for infectious disease modelling and therapeutics
    (World Scientific, 2020-11) Alterovitz, Gil; Alterovitz, Wei-Lun; Cassell, Gail H.; Zhang, Lixin; Dunker, A. Keith; Biochemistry and Molecular Biology, School of Medicine
    AI for infectious disease modelling and therapeutics is an emerging area that leverages new computational approaches and data in this area. Genomics, proteomics, biomedical literature, social media, and other resources are proving to be critical tools to help understand and solve complicated issues ranging from understanding the process of infection, diagnosis and discovery of the precise molecular details, to developing possible interventions and safety profiling of possible treatments.
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    Many-to-one binding by intrinsically disordered protein regions
    (WORLD SCIENTIFIC, 2019-11-02) Alterovitz, Wei-Lun; Faraggi, Eshel; Oldfield, Christopher J.; Meng, Jingwei; Xue, Bin; Huang, Fei; Romero, Pedro; Kloczkowski, Andrzej; Uversky, Vladimir N.; Dunker, A. Keith; Biochemistry and Molecular Biology, School of Medicine
    Disordered binding regions (DBRs), which are embedded within intrinsically disordered proteins or regions (IDPs or IDRs), enable IDPs or IDRs to mediate multiple protein-protein interactions. DBR-protein complexes were collected from the Protein Data Bank for which two or more DBRs having different amino acid sequences bind to the same (100% sequence identical) globular protein partner, a type of interaction herein called many-to-one binding. Two distinct binding profiles were identified: independent and overlapping. For the overlapping binding profiles, the distinct DBRs interact by means of almost identical binding sites (herein called “similar”), or the binding sites contain both common and divergent interaction residues (herein called “intersecting”). Further analysis of the sequence and structural differences among these three groups indicate how IDP flexibility allows different segments to adjust to similar, intersecting, and independent binding pockets.