Browsing by Author "Alruwaii, Zainab I."

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    The Pathologic and Molecular Genetic Landscape of the Hereditary Renal Cancer Predisposition Syndromes
    (Wiley, 2022) Al-Obaidy, Khaleel I.; Alruwaii, Zainab I.; Williamson, Sean R.; Cheng, Liang; Pathology and Laboratory Medicine, School of Medicine
    It is estimated that 5-8% of renal tumors are hereditary in nature with many inherited as autosomal dominant. These tumors carry a unique spectrum of pathologic and molecular alterations, the knowledge of which is expanding in the recent years. Indebted to this knowledge, many advances in treatment of these tumors have been achieved. In this review, we summarize the current understanding of the genetic renal neoplasia syndromes, the clinical and pathologic presentations, their molecular pathogenesis, the advances in therapeutic implications and targeted therapy.