Browsing by Author "Almahmoud, Sana"

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    Clinical Outcomes and Severity of Acute Respiratory Distress Syndrome in 1154 COVID-19 Patients: An Experience Multicenter Retrospective Cohort Study
    (MDPI, 2022) Al Mutair, Abbas; Alhumaid, Saad; Layqah, Laila; Shamou, Jinan; Ahmed, Gasmelseed Y.; Chagla, Hiba; Alsalman, Khulud; Alnasser, Fadhah Mohammed; Thoyaja, Koritala; Alhuqbani, Waad N.; Alghadeer, Mohammed; Al Mohaini, Mohammed; Almahmoud, Sana; Al-Tawfiq, Jaffar A.; Muhammad, Javed; Al-Jamea, Lamiaa H.; Woodman, Alexander; Alsaleh, Ahmed; Alsedrah, Abdulaziz M.; Alharbi, Hanan F.; Saha, Chandni; Rabaan, Ali A.; Medicine, School of Medicine
    Background: Acute Respiratory Distress Syndrome (ARDS) is caused by non-cardiogenic pulmonary edema and occurs in critically ill patients. It is one of the fatal complications observed among severe COVID-19 cases managed in intensive care units (ICU). Supportive lung-protective ventilation and prone positioning remain the mainstay interventions. Purpose: We describe the severity of ARDS, clinical outcomes, and management of ICU patients with laboratory-confirmed COVID-19 infection in multiple Saudi hospitals. Methods: A multicenter retrospective cohort study was conducted of critically ill patients who were admitted to the ICU with COVID-19 and developed ARDS. Results: During our study, 1154 patients experienced ARDS: 591 (51.2%) with severe, 415 (36.0%) with moderate, and 148 (12.8%) with mild ARDS. The mean sequential organ failure assessment (SOFA) score was significantly higher in severe ARDS with COVID-19 (6 ± 5, p = 0.006). Kaplan–Meier survival analysis showed COVID-19 patients with mild ARDS had a significantly higher survival rate compared to COVID-19 patients who experienced severe ARDS (p = 0.023). Conclusion: ARDS is a challenging condition complicating COVID-19 infection. It carries significant morbidity and results in elevated mortality. ARDS requires protective mechanical ventilation and other critical care supportive measures. The severity of ARDS is associated significantly with the rate of death among the patients.
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    Extracorporeal membrane oxygenation support for SARS-CoV-2: a multi-centered, prospective, observational study in critically ill 92 patients in Saudi Arabia
    (BMC, 2021-12-09) Alhumaid, Saad; Al Mutair, Abbas; Alghazal, Header A.; Alhaddad, Ali J.; Al‑Helal, Hassan; Al Salman, Sadiq A.; Alali, Jalal; Almahmoud, Sana; Alhejy, Zulfa M.; Albagshi, Ahmad A.; Muhammad, Javed; Khan, Amjad; Sulaiman, Tarek; Al‑Mozaini, Maha; Dhama, Kuldeep; Al‑Tawfiq, Jaffar A.; Rabaan, Ali A.; Medicine, School of Medicine
    Background: Extracorporeal membrane oxygenation (ECMO) has been used as a rescue strategy in patients with severe with acute respiratory distress syndrome (ARDS) due to SARS-CoV-2 infection, but there has been little evidence of its efficacy. Objectives: To describe the effect of ECMO rescue therapy on patient-important outcomes in patients with severe SARS-CoV-2. Methods: A case series study was conducted for the laboratory-confirmed SARS-CoV-2 patients who were admitted to the ICUs of 22 Saudi hospitals, between March 1, 2020, and October 30, 2020, by reviewing patient's medical records prospectively. Results: ECMO use was associated with higher in-hospital mortality (40.2% vs. 48.9%; p = 0.000); lower COVID-19 virological cure (41.3% vs 14.1%, p = 0.000); and longer hospitalization (20.2 days vs 29.1 days; p = 0.000), ICU stay (12.6 vs 26 days; p = 0.000) and mechanical ventilation use (14.2 days vs 22.4 days; p = 0.000) compared to non-ECMO group. Also, there was a high number of patients with septic shock (19.6%) and multiple organ failure (10.9%); and more complications occurred at any time during hospitalization [pneumothorax (5% vs 29.3%, p = 0.000), bleeding requiring blood transfusion (7.1% vs 38%, p = 0.000), pulmonary embolism (6.4% vs 15.2%, p = 0.016), and gastrointestinal bleeding (3.3% vs 8.7%, p = 0.017)] in the ECMO group. However, PaO2 was significantly higher in the 72-h post-ECMO initiation group and PCO2 was significantly lower in the 72-h post-ECMO start group than those in the 12-h pre-ECMO group (62.9 vs. 70 mmHg, p = 0.002 and 61.8 vs. 51 mmHg, p = 0.042, respectively). Conclusion: Following the use of ECMO, the mortality rate of patients and length of ICU and hospital stay were not improved. However, these findings need to be carefully interpreted, as most of our cohort patients were relatively old and had multiple severe comorbidities. Future randomized trials, although challenging to conduct, are highly needed to confirm or dispute reported observations.
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    Retraction Note: Extracorporeal membrane oxygenation support for SARS-CoV-2: a multi-centered, prospective, observational study in critically ill 92 patients in Saudi Arabia
    (Springer Nature, 2024-12-30) Alhumaid, Saad; Al Mutair, Abbas; Alghazal, Header A.; Alhaddad, Ali J.; Al‑Helal, Hassan; Al Salman, Sadiq A.; Alali, Jalal; Almahmoud, Sana; Alhejy, Zulfa M.; Albagshi, Ahmad A.; Muhammad, Javed; Khan, Amjad; Sulaiman, Tarek; Al‑Mozaini, Maha; Dhama, Kuldeep; Al‑Tawfiq, Jaffar A.; Rabaan, Ali A.; Medicine, School of Medicine
    This retracts the article "RETRACTED ARTICLE: Extracorporeal membrane oxygenation support for SARS-CoV-2: a multi-centered, prospective, observational study in critically ill 92 patients in Saudi Arabia" in volume 26, 141. The Editor-in-Chief has retracted this article. After publication concerns were raised about the methodology of the study reported. The Editor-in-Chief no longer has confidence in the results and conclusions presented. All authors disagree with this retraction.