Browsing by Author "Alenazi, Mansour Moklif"

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    Safety and Reactogenicity of the ChAdOx1 (AZD1222) COVID-19 Vaccine in Saudi Arabia
    (Elsevier, 2021-09) Al Bahrani, Salma; Albarrak, Ali; Alghamdi, Othman Ali; Alghamdi, Mesfer Abdullah; Hakami, Fatimah H.; Al Abaadi, Asmaa K.; Alkhrashi, Sausan A.; Alghamdi, Mansour Y.; Almershad, Meshael M.; Alenazi, Mansour Moklif; El Gezery, Mohamed Hany; Jebakumar, Arulanantham Zechariah; Al-Tawfiq, Jaffar A.; Medicine, School of Medicine
    Introduction The Kingdom of Saudi Arabia was one of the first countries to implement a COVID-19 vaccination program. This study estimated the safety and reactogenicity of the ChAdOx1-S vaccine after the first dose administered to adults. Methods This cross-sectional study included 1592 randomly selected vaccinees from April to May 2021. A questionnaire was delivered to the vaccinees via phone calls 7 and 21 days after the first vaccine dose. Results Of the 1592 vaccinees who had the first dose, the mean age was 37.4 (± 9.6) years and 81% were males. Of all the vaccinees, 553 (34.7%) reported an adverse reaction on the first telephone call. The most common symptoms were: pain at the site of injection (485, 30.5%), musculoskeletal symptoms (438, 27.5%), skin rash (307, 19.2%), gastrointestinal symptoms (379, 23.8%) and fever (498, 31.3%). Men were more likely to report fever (76.9% vs. 23.1%; P = 0.005), skin rash (81.1% vs. 18.9%, P = 0.005) and pain at the injection site (77.3% vs. 22.7%, P < 0.0001). Post-vaccine COVID-19 infection was 0.5% and there were no hospitalizations. Conclusion This study observed no major side effects of the ChAdOx1-S vaccine and no reported breakthrough infection during the observation period.