Browsing by Author "Ahuja, Parul"

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    Awareness data on cervical cancer among females of rural and urban areas of Haryana, India
    (Elsevier, 2024-02-07) Yadav, Ritu; Chauhan, Meenakshi B.; Yadav, Chetna; Ranga, Shalu; Ahuja, Parul; Tanwar, Mukesh; Balhara, Nikita; Kadian, Lokesh; Chauhan, Preeti; Tanwar, Neha; Ahlawat, Chavi; Medicine, School of Medicine
    A cross-sectional study was done to assess the degree of current awareness and behaviors about cervical cancer among females in urban and rural areas of North India. This survey was conducted on one thousand females (500 rural and 500 urban). A well-structured questionnaire was designed to collect information about participants’ knowledge on cancer of cervix uteri such as age, height and weight measurements, marital status, menstrual status, personal hygiene, age at menarche, sexual history, pregnancy and abortion history, use of contraceptive pills for birth-control, smoking, alcohol consumption, and other relevant information. The data was collected by conducting face-to-face interviews after obtaining the verbal consent of the participants. The data has the potential to reduce disease burden by spreading awareness about symptoms and risk factors of cervical cancer as well as implementation of effective early screening strategies.
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    Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives
    (Springer Nature, 2023) Ranga, Shalu; Yadav, Ritu; Chhabra, Ravindresh; Chauhan, Meenakshi B.; Tanwar, Mukesh; Yadav, Chetna; Kadian, Lokesh; Ahuja, Parul; Medicine, School of Medicine
    Cervical cancer is among the leading causes of cancer-associated mortality in women. In spite of vaccine availability, improved screening procedures, and chemoradiation therapy, cervical cancer remains the most commonly diagnosed cancer in 23 countries and the leading cause of cancer deaths in 36 countries. There is, therefore, a need to come up with novel diagnostic and therapeutic targets. Long non-coding RNAs (lncRNAs) play a remarkable role in genome regulation and contribute significantly to several developmental and disease pathways. The deregulation of lncRNAs is often observed in cancer patients, where they are shown to affect multiple cellular processes, including cell cycle, apoptosis, angiogenesis, and invasion. Many lncRNAs are found to be involved in the pathogenesis as well as progression of cervical cancer and have shown potency to track metastatic events. This review provides an overview of lncRNA mediated regulation of cervical carcinogenesis and highlights their potential as diagnostic and prognostic biomarkers as well as therapeutic targets for cervical cancer. In addition, it also discusses the challenges associated with the clinical implication of lncRNAs in cervical cancer.