Browsing by Author "Adow, Ahmed"

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    Identification of N-benzyltetrahydroisoquinolines as novel anti-neuroinflammatory agents
    (Elsevier, 2018-11) Gabet, Brian; Kuo, Ping-Chang; Fuentes, Steven; Patel, Yamini; Adow, Ahmed; Alsakka, Mary; Avila, Paula; Beam, Teri; Yen, Jui-Hung; Brown, Dennis A.; Medicine, School of Medicine
    A series of simplified berberine analogs was designed, synthesized, and evaluated for anti-inflammatory activity. SAR studies identified N-benzyltetrahydroisoquinoline 7d as a potent berberine analog. 7d suppressed LPS-induced inflammatory cytokine levels in both BV2 cells and primary microglia. Taken together, our results suggest that simplified BB analogs have therapeutic potential as a novel class of anti-neuroinflammatory agents.