Global approaches for profiling transcription initiation
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Date
2021
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American English
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Elsevier
Abstract
Transcription start site (TSS) selection influences transcript stability and translation as well as protein sequence. Alternative TSS usage is pervasive in organismal development, is a major contributor to transcript isoform diversity in humans, and is frequently observed in human diseases including cancer. In this review, we discuss the breadth of techniques that have been used to globally profile TSSs and the resulting insights into gene regulation, as well as future prospects in this area of inquiry.
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Policastro RA, Zentner GE. Global approaches for profiling transcription initiation. Cell Rep Methods. 2021;1(5):100081. doi:10.1016/j.crmeth.2021.100081
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Cell Reports Medicine
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PMC
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Article
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Final published version