Immune Checkpoints and Pancreatic Beta Cell Dysfunction in HIV
Date
2024
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American English
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Wolters Kluwer
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Abstract
We explored the impact of immune dysregulation on pancreatic beta cell injury in HIV patients. Analyzing 105 participant samples, we observed lower IL-21 levels and elevated immune checkpoint levels (e.g. PD-1, CD27+, CD40+) in untreated HIV patients. Notably, soluble TIM-3 correlated positively with improved beta cell function and inversely with beta cell stress, suggesting its potential role in beta cell protection in untreated HIV.
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Cite As
Pryke LA, Liu Z, Khaitan AK, Sims EK, Gupta SK. Immune checkpoints and pancreatic beta cell dysfunction in HIV. AIDS. 2024;38(11):1725-1727. doi:10.1097/QAD.0000000000003932
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AIDS
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PMC
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Article
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Author's manuscript