The TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis
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2011
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American English
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American Association for Cancer Research
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Abstract
The Hedgehog (HH) and TGF-β signaling pathways represent essential regulators of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a characteristic of various cancers. Recently, evidence for a convergence of these pathways at the level of the GLI2 transcription factor in the context of tumor initiation and progression to metastasis has emerged. This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-β in cancer.
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Cite As
Javelaud D, Alexaki VI, Dennler S, Mohammad KS, Guise TA, Mauviel A. TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis. Cancer Res. 2011;71(17):5606-5610. doi:10.1158/0008-5472.CAN-11-1194
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Cancer Research
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PMC
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Article
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Author's manuscript