Operationalizing a research-oriented learning healthcare system across covered entities: cross-institutional strategies and innovations

Abstract

The concept of a Learning Health System (LHS) has been widely discussed in academic literature, yet its practical implementation remains a challenge. This paper describes the institutional journey, leadership structure, data governance policies, and technical innovations that together support a scalable and sustainable Research-Oriented LHS. Additionally, we propose an expanded data vision that aligns with interdisciplinary and translational research needs. Supplementary materials provide technical details for those interested in implementing such a model.

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Huerta TR, Bartlett CW, Alain G, et al. Operationalizing a research-oriented learning healthcare system across covered entities: cross-institutional strategies and innovations. Npj Health Syst. 2025;2(1):47. doi:10.1038/s44401-025-00051-2
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npj Health Systems
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PMC
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Article
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