Nuclear Protein Isoforms: Implications for Cancer Diagnosis and Therapy
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2011
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American English
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Wiley
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Abstract
Post-translational modifications (PTMs) of nuclear proteins play essential roles in the regulation of gene transcription and signal transduction pathways. Numerous studies have demonstrated a correlation between specific nuclear protein isoforms and cellular malignant process. This communication reviews the impact of major PTM events such as phosphorylation, acetylation, methylation, ubiquitination, and sumoylation on several important nuclear proteins including p53, histones, proliferating cellular nuclear antigen (PCNA), and retinoblastoma protein (Rb) in the process. In addition, the implications of the PTMs as cancer biomarkers and therapeutic targets are considered.
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Cite As
Shen F, Kirmani KZ, Xiao Z, Thirlby BH, Hickey RJ, Malkas LH. Nuclear protein isoforms: implications for cancer diagnosis and therapy. J Cell Biochem. 2011;112(3):756-760. doi:10.1002/jcb.23002
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Journal of Cellular Biochemistry
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PMC
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Article
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Author's manuscript