Short- and Long-Term Outcomes Associated with Large for Gestational Age Birth Weight

Abstract

Large for gestational age (LGA) birth weight is associated with multiple adverse short- and long-term outcomes. Infants born with LGA birth weight are at increased risk for NICU admission, respiratory distress, neonatal metabolic abnormalities including hypoglycemia, birth trauma, and even stillbirth or neonatal death. The risk for many of these complications increases with higher birth weights. Individuals with LGA birth weight also appear to be at subsequent increased risk for overweight/obesity, diabetes, cardiovascular disease, and even some childhood cancers. These data highlight the need for effective interventions to reduce risk across the lifespan.