Association of cardiovascular disease with dementia: A longitudinal analysis using National Alzheimer's Coordinating Center data
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2025-08-21
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American English
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Abstract
We analyzed how cardiovascular disease subtypes influence the prevalence and incidence of dementia among 30,582 individuals aged 50 and older in the National Alzheimer's Coordinating Center cohort. We calculated prevalence ratios (aPR) and hazard ratios (aHR), using models adjusted for age, sex, race, years of education, hypertension, diabetes, and dyslipidemia. Stroke (aPR: 1.26; 95% CI: 1.20-1.32) and history of arrhythmias (aPR: 1.17; 95% CI: 1.09-1.24) were associated with higher dementia prevalence. In survival analysis, stroke was associated with a 55% increased risk of incident dementia (aHR: 1.55; 95% CI: 1.36-1.77).
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Cite As
Summanwar D, Kim H, Wei J, Boustani M, Alonso A, Kulshreshtha A. Association of cardiovascular disease with dementia: A longitudinal analysis using National Alzheimer's Coordinating Center data. J Alzheimers Dis Rep. 2025;9:25424823251370646. Published 2025 Aug 21. doi:10.1177/25424823251370646
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Journal of Alzheimer's Disease Reports
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PMC
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Article
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