Genetic mapping and phenotypic analysis of shotH.3.2 in Drosophila melanogaster
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2021-07-13
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American English
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MicroPubl Biol
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Abstract
Abstract: Genetic screens are used to identify genes involved in specific biological processes. An EMS mutagenesis screen in Drosophila melanogaster identified growth control phenotypes in the developing eye. One mutant line from this screen, H.3.2, was phenotypically characterized using the FLP/FRT system and genetically mapped by complementation analysis and genomic sequencing by undergraduate students participating in the multi-institution Fly-CURE consortium. H.3.2 was found to have a nonsense mutation in short stop (shot), anortholog of the mammalian spectraplakin dystonin (DST). shot and DST are involved in cytoskeletal organization and play roles during cell growth and proliferation.
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Cite As
Talley EM, Watts CT, Aboyer S, Adamson MG, Akoto HA, Altemus H, Avella PJ, Bailey R, Bell ER, Bell KL, Breneman K, Merkle JA et al. Genetic mapping and phenotypic analysis of shotH.3.2 in Drosophila melanogaster. MicroPubl Biol. 2021 Jul 13;2021:10.17912/micropub.biology.000418. doi: 10.17912/micropub.biology.000418. PMID: 34278244; PMCID: PMC8278230
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Article