Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Abstract

Correction to: Nature Genetics 10.1038/s41588-024-01939-9, published online 8 October 2024. After publication of the article, several collaborators helpfully pointed out issues with genetic variant ID harmonization and effect allele coding errors, each affecting a subset of variants used in our study. The authors regret these errors and have updated the manuscript and summary statistics to correct them. Most results reported in the manuscript were not materially affected by this; however, the lead variant in the reported PIK3R5 locus associated with Braak neurofibrillary tangle (NFT) stage no longer reached genome-wide significance after correction (now P = 1.3 × 10−7). Furthermore, the known Alzheimer’s Disease and related dementias (ADRD) loci CELF1/SPI1 (Braak NFT stage and CERAD score) and TMEM106B (Braak NFT stage) now reach the FDR significance threshold for association with at least one additional neuropathology endophenotype (NPE). Other results, namely P values, effect sizes and colocalization probabilities have minor changes and have been corrected throughout. Several minor typos are now also corrected. We also corrected all tables and figures based on genome-wide association study (GWAS) summary statistics. The Supplementary Information accompanying this amendment shows a detailed list of all updates. All changes discussed are reflected in the HTML and PDF versions of the article. The authors thank Sven van der Lee and Niccoló Tesi for pointing out the errors in variant harmonization and effect allele coding.