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Item Daily Situational Brief, February 13, 2015(MESH Coalition, 2/13/2015) MESH CoalitionItem Promoting TEFCA with Blockchain Technology: A Decentralized Approach to Patient-centered Healthcare Data Management(AMIA, 2023) Zhuang, Yan; Zhang, Luxia; BioHealth Informatics, School of Informatics and ComputingThe Trusted Exchange Framework and Common Agreement (TEFCA) is a framework consisting of seven principles designed to create a secure and seamless health information exchange system across various healthcare settings. The ultimate goal of TEFCA is to facilitate public health surveillance, increase interoperability, promote data sharing, and ensure patient-centered healthcare data management. While the implementation of these principles is challenging, blockchain technology, with its unique features such as transparency, auditability, immutability, and anonymity, can provide a promising solution to the development of TEFCA. This article delves into the potential of blockchain technology to promote TEFCA design. By providing an immutable and transparent ledger, blockchain ensures data integrity, openness, and patient privacy. Overall, the use of blockchain technology can help address the challenges of implementing TEFCA principles and promote patient empowerment and control over their health data, improve data interoperability, and enhance healthcare quality.