Browsing by Subject "antibacterial activity"

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    A NOVEL ANTIBACTERIAL RESIN COMPOSITE CONTAINING QUATERNARY AMMONIUM SALTS
    (Office of the Vice Chancellor for Research, 2012-04-13) Howard, Leah; Weng, Yiming; Guo, Xia; Chong, Voon Joe; Gregory, Richard L.; Xie, Dong
    Objectives: The objective of this study was to synthesize new quater-nary ammonium bromide (QAB)-containing oligomers, incorporate them to dental resin composites, and evaluate the effects of these new oligo-mers on the mechanical strength and antibacterial activity of the formed composites. Methods: The novel quaternary ammonium bromide (QAB)-containing oligomers were synthesized and applied for developing an an-tibacterial resin composite. Compressive strength (CS) and S. mutans (an oral bacteria strain) viability were used to evaluate the mechanical strength and antibacterial activity of the formed composites. Results: All the QAB-modified resin composites showed significant antibacterial activi-ty and mechanical strength reduction. Increasing chain length and loading significantly enhanced the antibacterial activity but dramatically reduced the CS. The 30-day aging study showed that the incorporation of the QAB accelerated the degradation of the composite, suggesting that the QAB may not be well suitable for development of antibacterial dental resin composites or at least the QAB loading should be well controlled, unlike its use in dental glass-ionomer cements. Conclusions: The work in this study is beneficial and valuable to those who are interested in studying antibacterial dental resin composites.