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Item Associations between affective traits and endothelial function in depressed adults(2018) Berntson, Jessica; Stewart, Jesse C.; Cyders, Melissa A.; Rand, Kevin L.; Gupta, Samir K.Depressed adults are at increased risk of developing atherosclerotic cardiovascular disease (CVD). However, heterogeneity in the depressed population engenders a key question: Are there subgroups of depressed adults at greater risk of developing CVD? Because other affective traits – i.e., anxiety, hostility/anger, and low trait positive affect – have also been associated with increased CVD risk, depressed adults with higher levels of these co-occurring affective traits may have an elevated risk of developing CVD. Consequently, the present study’s first aim was to examine, in depressed adults, which affective traits (depression, anxiety, hostility/anger, or low positive affect) are associated with endothelial function, a marker of cumulative CVD risk. In addition, because the other affective traits overlap with depressive symptom severity, this study’s second aim was to investigate which components of pairs of affective traits (shared versus unique) are related to endothelial function. Finally, given that the mechanisms underlying affective trait-endothelial function relationships in depressed adults are unknown, this study’s third aim was to explore traditional CVD risk status as a candidate mediator of observed relationships. To achieve these aims, I combined pre-treatment, cross-sectional data from three randomized controlled trials involving 138 depressed primary care patients with no history of clinical CVD. Assessments included validated self-report questionnaires for affective traits, brachial artery flow-mediated dilation (FMD) for endothelial function, and 10-year Framingham risk score for traditional CVD risk status. I conducted structural equation modeling (SEM) with confirmatory factor analysis to examine the relationships of interest after adjusting for age, sex, race/ethnicity, education, and baseline arterial diameter. Although the shared variance between each affective trait pair could not be modeled due to poor fit, adequate fitting models revealed that hostility/anger and the unique components of hostility/anger were associated with poorer endothelial function (standardized coefficients = -.18 and -.22, respectively). All of the other affective traits and their components (depression, anxiety, positive affect, unique depression, unique anxiety, and unique positive affect) were not related to endothelial function (all ps > .08). Traditional CVD risk status did not partially explain the relationship between the unique components of hostility/anger and endothelial function (standardized coefficient for the indirect effect = .00; p = .89). If my results are supported by future findings, it would suggest that depressed adults with hostility/anger (a) may be a subgroup of the depressed population at greater risk of developing CVD and (b) may be in need of earlier, more intense, and/or different CVD primary prevention efforts. Future studies are needed to confirm this relationship and identify underlying mechanisms.Item The Creation and Validation of the Activation-Valence Affective Traits Survey (AVATS)(2012-07-03) Coskunpinar, Ayca; Cyders, Melissa A.; Devine, Dennis J. (Dennis John); Stewart, Jesse C.Aim: The goals of the current studies were to (a) create a measure of affective traits that can assess both the discrete and the underlying dimensions of affective traits and (b) examine the reliability and validity of the scale in two independent samples. Participants: Participants were undergraduate students at a large, public US mid-western university (Study 1 N = 616; Study 2 N = 510). The mean age for Study 1 was 21.10 (SD = 5.05) and 21.02 for Study 2 (SD = 4.96). Design: Exploratory and confirmatory factor analyses were conducted to examine internal factor structure of the scale. A series of correlational, reliability, and hierarchical regression analyses were conducted to examine convergent, divergent, and criterion-related validity of the new scale. Findings: Activation-Valence Affective Traits Survey (AVATS) had good reliability and adequate construct, convergent, and discriminant validity as a measure of affective traits. Conclusions: This study introduces a new scale for measuring affective traits that offers more information on both the categorical and dimensional conceptualizations of affective traits, which also has predictive utility in relation to problem-related alcohol consumption.Item Mechanisms Underlying the Relationship between Negative Affectivity and Problematic Alcohol Use(Office of the Vice Chancellor for Research, 2013-04-05) Coskunpinar, Ayca; Dir, Allyson L.; Karyadi, Kenny A.; Koo, ChungSeungResearch has long supported the role of negative affectivity for problematic alcohol consumption (Bechara, 2005; Dolan, 2007; Larsen, 2000; Tice & Bratslavsky, 2000; Tice, Bratslavsky, & Baumeister, 2001). However, the mechanisms that underlie how negative affective traits influence problematic alcohol use and attentional biases are not well understood. These inconsistencies can be attributed to three possible reasons: (1) research has often utilized broad measures of negative affective traits that can mask the effect of specific underlying unidimensional traits (Smith, Fischer & Fister, 2003), (2) research has tended to utilize only the valence of traits and has often failed to consider how activation of traits might predict behavioral outcomes, and (3) research has not fully incorporated other aspects of affective traits (e.g. affective lability and emotion-based rash action) that could be serving as mechanisms in predicting problematic alcohol use. The current study sought to characterize mechanisms that drive problematic alcohol use and attentional biases. Three undergraduate student studies were conducted (n = 510, 429, and 38). Negative urgency partially mediated the effects of negative affectivity (B for indirect effect = .119, CI = .09 – .16) and affect lability (B for indirect effect = .928, CI = .47 – 1.45) on problematic alcohol use. Activation level of hostility predicted increased variance in problematic alcohol consumption (R2 change = .01, β = .16, p = .02) above trait valence. Negative urgency predicted alcohol attentional biases over and above valence and activation (β = 2.23, p = .05). Negative urgency is a prime mechanism by which negative affective traits influence problematic alcohol consumption. This suggests that the relationship between negative urgency or lack of planning and problematic alcohol consumption could be driven, in part, by increases in attentional biases when cued with alcohol stimuli, although this was not directly tested in the current study.