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Item Active viral shedding in a vaccinated hospitalized patient infected with the delta variant (B.1.617.2) of SARS-CoV-2 and challenges of de-isolation(Elsevier, 2022) Alshukairi, Abeer N.; Al-Omari, Awad; Al-Tawfiq, Jaffar A.; El-Kafrawy, Sherif A.; El-Daly, Mai M.; Hassan, Ahmed M.; Faizo, Arwa A.; Alandijany, Thamir A.; Dada, Ashraf; Saeedi, Mohammed F.; Alhamlan, Fatma S.; Al Hroub, Mohammad K.; Qushmaq, Ismael; Azhar, Esam I.; Medicine, School of MedicineIn the era of SARS-CoV-2 variants and COVID-19 vaccination, the duration of infectious viral shedding and isolation in post vaccine breakthrough infections is challenging and depends on disease severity. The current study described a case of SARS-CoV-2 Delta variant pneumonia requiring hospitalization. The patient received two doses of BNT162b2 COVID-19 vaccines, and he had positive SARS-CoV-2 viral cultures 12 days post symptom onset. The time between the second dose of vaccine and the breakthrough infection was 6 months. While immunosuppression is a known risk factor for prolonged infectious viral shedding, age and time between vaccination and breakthrough infection are important risk factors that warrant further studies.