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Item Assessment of Orthodontic Treatment Results and Comparison between Fixed Lingual and Labial Appliances(2001) Pinskaya, Yuliya B.; Roberts, W. Eugene; Baldwin, James J.; Hartsfield, James K., Jr.; Hohlt, William F.; Shanks, James C.Interest in objective assessment of orthodontic treatment outcomes and in quality control of orthodontic treatment is increasing. In recent years, the evaluation of orthodontic treatment results has been carried out with the help of various indices or different rating systems. No published studies have used the ABO Objective Grading System for evaluation of orthodontic treatment outcomes for all cases in the clinical series. There are also very few studies, conducted mainly in Europe, that have assessed treatment results in postgraduate orthodontic clinics. There is one known study comparing treatment results between fixed lingual and labial appliances. The objectives of the present study were: first, to assess treatment outcomes in the IUSD Graduate Orthodontic Clinic for three years (1998, 1999, and 2000); and second, to compare treatment results achieved with the use of fixed lingual and labial appliances. Pre and posttreatment records (study casts, panoramic and lateral cephalometric radiographs, and extraoral and intraoral photographs) of 521 patients treated in the IUSD Graduate Orthodontic Clinic were evaluated. Treatment outcomes were assessed for a 3-year period using the ABO Grading System and IUSD Comprehensive Clinical Assessment Criteria. Statistically significant differences were found for the majority of the evaluation criteria between the selected three years. The overall quality of finished cases decreased from 1998 to 2000. This trend may reflect preferential finishing of the cases that were going well and transferring all the other cases. No assumptions regarding the overall performance of the Clinic should be made based on the results of this study. It should be remembered that these three years were selected for a particular reason. In the fall of 1997, a clinical grading program was initiated. All active cases (1997-98 academic year) were to be finished within three years. The year 2000 was the deadline to finish all active long treatment time cases. Most of the cases that were in treatment for a long time were progressing poorly and were not finally finished until 2000. This group of difficult cases contributed to the decreased quality of the finished cases and longer treatment time during the year 2000 compared to 1998 and 1999. It is anticipated that treatment outcomes will improve in 2001 since the backlog o flong treatment time cases has been cleared. The evaluation of this three-year period (1998-2000) was the baseline evaluation for comparison of finished cases for subsequent years. When comparing treatment results between fixed lingual and labial appliances, significant differences were found for only 4 of 24 parameters. These outcome differences were, mainly, due to the inherent characteristics of the lingual appliance rather than to the treatment approach of the supervising instructor. Even though statistically significant differences were found for a few parameters between two types of appliances, they did not indicate the advantages of one appliance over the other. The present study suggests that the treatment results can be as good with lingual as with labial appliances. This study also has established a baseline for comparison of clinical outcomes in the IUSD Orthodontic Clinic for subsequent years.Item Assessment of Orthodontic Treatment Results: Two-Phase Treatment (Early Intervention) vs. One-Phase Treatment (Late Intervention)(2003) Hsieh, Tsung-Ju; Roberts, W. Eugene; Baldwin, James J.; Hohlt, William F.; Kowolik, Michael J.; Shanks, James C.There is still a lack of consensus among orthodontists regarding the degree of success of different treatment modalities applied during the early to late mixed dentition stages. The purpose of this study was to compare the treatment outcome of one-phase with two-phase treatment with objective evaluation criteria. The null hypothesis is that there is no difference in the treatment quality between early and late treatment groups, among cases finished in year 1998, 1999 and 2000 or among three Angle's Classes or between extraction and non-extraction cases. Pre-treatment and post-treatment records of all patients treated in the orthodontic clinic at the Indiana University School of Dentistry who had their treatment completed during the three years (1998, 1999, 2000) were evaluated by American Board of Orthodontics (ABO) objective grading system and clinical assessment criteria developed in the IUSD orthodontic section. The results of the study showed that there were 512 cases finished in these 3 years. Among these 512 cases the treatment was most often started at age 12, followed by age 13. Poor occlusal contact and improper third order of molars, longer treatment time, and poor dentition were major contributors that made the treatment quality poor. Early debond tended to occur more often with boys than girls. Generally Angle's Class I cases and the cases finished in year 1998 had better treatment results. Although the early treatment group had longer treatment time than late treatment group, the final treatment quality was comparable with that of the late treatment group.Item Atomoxetine improved attention in children and adolescents with attention-deficit/hyperactivity disorder and dyslexia in a 16 week, acute, randomized, double-blind trial(Mary Ann Liebert, 2013-11) Wietecha, Linda; Williams, David; Shaywitz, Sally; Shaywitz, Bennett; Hooper, Stephen R.; Wigal, Sharon B.; Dunn, David; McBurnett, Keith; Pediatrics, School of MedicineOBJECTIVE: The purpose of this study was to evaluate atomoxetine treatment effects in attention-deficit/hyperactivity disorder (ADHD-only), attention-deficit/hyperactivity disorder with comorbid dyslexia (ADHD+D), or dyslexia only on ADHD core symptoms and on sluggish cognitive tempo (SCT), working memory, life performance, and self-concept. METHODS: Children and adolescents (10-16 years of age) with ADHD+D (n=124), dyslexia-only (n=58), or ADHD-only (n=27) received atomoxetine (1.0-1.4 mg/kg/day) or placebo (ADHD-only subjects received atomoxetine) in a 16 week, acute, randomized, double-blind trial with a 16 week, open-label extension phase (atomoxetine treatment only). Changes from baseline were assessed to weeks 16 and 32 in ADHD Rating Scale-IV-Parent-Version:Investigator-Administered and Scored (ADHDRS-IV-Parent:Inv); ADHD Rating Scale-IV-Teacher-Version (ADHDRS-IV-Teacher-Version); Life Participation Scale-Child- or Parent-Rated Version (LPS); Kiddie-Sluggish Cognitive Tempo (K-SCT) Interview; Multidimensional Self Concept Scale (MSCS); and Working Memory Test Battery for Children (WMTB-C). RESULTS: At week 16, atomoxetine treatment resulted in significant (p<0.05) improvement from baseline in subjects with ADHD+D versus placebo on ADHDRS-IV-Parent:Inv Total (primary outcome) and subscales, ADHDRS-IV-Teacher-Version Inattentive subscale, K-SCT Interview Parent and Teacher subscales, and WMTB-C Central Executive component scores; in subjects with Dyslexia-only, atomoxetine versus placebo significantly improved K-SCT Youth subscale scores from baseline. At Week 32, atomoxetine-treated ADHD+D subjects significantly improved from baseline on all measures except MSCS Family subscale and WMTB-C Central Executive and Visuo-spatial Sketchpad component scores. The atomoxetine-treated dyslexia-only subjects significantly improved from baseline to week 32 on ADHDRS-IV-Parent:Inv Inattentive subscale, K-SCT Parent and Teacher subscales, and WMTB-C Phonological Loop and Central Executive component scores. The atomoxetine-treated ADHD-only subjects significantly improved from baseline to Week 32 on ADHDRS-Parent:Inv Total and subscales, ADHDRS-IV-Teacher-Version Hyperactive/Impulsive subscale, LPS Self-Control and Total, all K-SCT subscales, and MSCS Academic and Competence subscale scores. CONCLUSIONS: Atomoxetine treatment improved ADHD symptoms in subjects with ADHD+D and ADHD-only, but not in subjects with dyslexia-only without ADHD. This is the first study to report significant effects of any medication on SCT.Item Cerebrospinal Fluid Leaks From the Lateral Ventricle: A Case Series(Wolters Kluwer, 2021-09) Saltagi, Mohamad Z.; Fraser, Amy L.; Alwani, Mohamedkazim M.; Mosier, Kristine M.; Nelson, Rick F.; Otolaryngology -- Head and Neck Surgery, School of MedicineOBJECTIVES: Describe the diagnosis and management of lateral skull base (LSB) cerebrospinal fluid (CSF) leaks originating from the lateral ventricle. STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral academic center. PATIENTS: Patients with CSF leaks with direct communication to the lateral ventricle on preoperative imaging. INTERVENTION: Surgical repair via the middle cranial fossa (MCF) approach. MAIN OUTCOME MEASURES: CSF leak patient characteristics (age, sex, body mass index [BMI]) and postoperative course (complications and CSF leak resolution) were collected. RESULTS: Three patients had CSF leaks from the lateral ventricle and all patients demonstrated encephalomalacia of the temporal lobe on preoperative imaging. Encephalomalacia resulted from trauma in one case (age 5) and neurodegeneration in two cases (age 77 and 84). BMI ranged from 16.3 to 26.6 mg/kg2 and follow-up ranged from 4 to 21 months. Two patients presented with preoperative meningitis and all patients had resolution of CSF leaks after MCF repair. With the exception of the higher rate of meningitis, patient presentations did not differ from other spontaneous CSF leaks through middle fossa defects. There were no minor or major postoperative complications. CONCLUSIONS: CSF leaks from the lateral ventricle represent a rare subset of LSB CSF leaks and can occur in non-obese patients secondary to temporal lobe encephalomalacia. The MCF approach allows for repair of the dura and skull base in this cohort of patients with high-flow CSF leaks and loss of brain parenchyma.Item Comparison of Electrosurgical and Formocresol Pulpotomy Procedures(1997) Fulkerson, Bradley Todd; Dean, Jeffrey A.; Avery, David R.; Sanders, Brian J.; Zunt, Susan L.; Legan, Joseph E.Formocresol is the most commonly used pharmacologic pulpotomy agent. Concerns over its safety have led investigators to search for new pulpotomy medicaments. This study compared the electrosurgical pulpotomy with the formocresol pulpotomy in teeth requiring pulp therapy after carious involvement. There were 25 pulpotomies performed in each group. The teeth were evaluated for clinical and radiographic success after at least six months. In the electrosurgical group, the clinical and radiographic success rates were 96 percent and 84 percent, respectively. The age range at the time of treatment was 26 to 97 months, with a mean treatment age of 63.6 months. The postoperative observation time range was six to 31 months, with the mean being 10.9 months. In the formocresol group, the clinical and radiographic success rates were 100 percent and 92 percent, respectively. The age range at the time of treatment was 32 to 126 months, with a mean treatment age of 68.2 months. The postoperative observation time ranged from five to 25 months, with the mean being 11.5 months. The electrosurgical and formocresol groups were compared for differences in the percentage of successes by using a Fisher's Exact test. There were no statistical differences between the two groups at the p < 0.05 level. Therefore, this study failed to demonstrate a statistically significant difference in the success rate between the electrosurgical and formocresol pulpotomy techniques and supports the use of the electrosurgical pulpotomy as a viable and safe alternative to formocresol.Item Comprehensive Evaluation of Posttreatment Skeletal, Dental and Soft Tissue Changes(2003) Martin, Daniel S.; Roberts, W. Eugene; Baldwin, James J.; Hohlt, William F.; Katona, Thomas R.; Shanks, James C.One of the most important challenges the orthodontist faces is producing an orthodontic result that is stable. While many investigators have analyzed postretention stability, they have focused on specific variables. These include lower incisor crowding, intercanine distance and arch form alteration. However, to effectively analyze posttreatment stability, one must also examine the occlusion, skeletal changes and soft tissue changes that. Thus, the objectives of this study were to: 1. Comprehensively evaluate posttreatment skeletal, dental and soft tissue changes and 2. compare the stability of cases from the Indiana University School of Dentistry (IUSD) Graduate Orthodontic Clinic to those of a private practitioner. The null hypotheses of this study were: 1. There were no significant differences (p <0.05) in the amount of change from immediately posttreatment to two years posttreatment for the 150 cases evaluated. 2. There were no significant differences (p < 0.05) in posttreatment stability between the IUSD Graduate Orthodontic Clinic and those treated by a private practitioner. 3. There were no significant differences (p <. 05) in the quality of finish between IUSD and private practice. One hundred dental records from the IUSD Graduate Orthodontic Clinic and fifty from the office of a private practitioner were used in this analysis. Posttreatment and two year posttreatment dental casts were scored according to the American Board of Orthodontics Grading System for Dental Casts and Panoramic Radiographs. Lateral cephalometric radiographs from three time points (pretreatment, immediately posttreatment and at least two years posttreatment) were traced and measured to assess posttreatment skeletal and soft tissue changes. Except for two of the individual ABO categories, none demonstrated statistically significant changes over the two year posttreatment period. There was a statistically significant increase in 1st order alignment score and a statistically significant decrease in occlusal contact score for this period. This indicates that there is a tendency for posttreatment rotational relapse. Also, the reduction in the occlusal contact score indicates a settling of the occlusion over the two year posttreatment period. Intercanine and intermolar measurements were made to assess arch form stability. It was found that there were statistically significant increases in upper and lower intercanine distances from pretreatment to posttreatment, but the amount of change between posttreatment and two years posttreatment was not statistically significant. Cephalometrically, several of the measurements demonstrated changes from pretreatment to posttreatment. The dental measures /1 (A-Pg) and 1/(FH) were significantly increased for this time period. Also, /1 (MP) was statistically decreased for this time period. The skeletal measures N-A-Pg, SNA and ANB were statistically lower at the completion of treatment. Lip protrusion was statistically reduced from pretreatment to either posttreatment time point. Although statistically significant differences were found in two of the parameters evaluated, the majority demonstrated no statistical significance. It is the conclusion of this investigation that posttreatment changes in most of the parameters studied are stable over a two year period.Item Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study(Public Library of Science, 2019-10-01) Elphinstone, Robyn E.; Weckman, Andrea M.; McDonald, Chloe R.; Tran, Vanessa; Zhong, Kathleen; Madanitsa, Mwayiwawo; Kalilani-Phiri, Linda; Khairallah, Carole; Taylor, Steve M.; Meshnick, Steven R.; Mwapasa, Victor; Ter Kuile, Feiko O.; Conroy, Andrea L.; Kain, Kevin C.; Pediatrics, School of MedicineMalaria in pregnancy is associated with adverse birth outcomes. However, the underlying mechanisms remain poorly understood. Tight regulation of angiogenic, metabolic, and inflammatory pathways are essential for healthy pregnancies. We hypothesized that malaria disrupts these pathways leading to preterm birth (PTB). Methods and findings We conducted a secondary analysis of a randomized trial of malaria prevention in pregnancy conducted in Malawi from July 21, 2011, to March 18, 2013. We longitudinally assessed circulating mediators of angiogenic, metabolic, and inflammatory pathways during pregnancy in a cohort of HIV-negative women (n = 1,628), with a median age of 21 years [18, 25], and 562 (35%) were primigravid. Pregnancies were ultrasound dated, and samples were analyzed at 13 to 23 weeks (Visit 1), 28 to 33 weeks (Visit 2), and/or 34 to 36 weeks (Visit 3). Malaria prevalence was high; 70% (n = 1,138) had PCR-positive Plasmodium falciparum infection at least once over the course of pregnancy and/or positive placental histology. The risk of delivering preterm in the entire cohort was 20% (n = 304/1506). Women with malaria before 24 weeks gestation had a higher risk of PTB (24% versus 18%, p = 0.005; adjusted relative risk [aRR] 1.30, 95% confidence interval [CI] 1.04–1.63, p = 0.021); and those who were malaria positive only before week 24 had an even greater risk of PTB (28% versus 17%, p = 0.02; with an aRR of 1.67, 95% CI 1.20–2.30, p = 0.002). Using linear mixed-effects modeling, malaria before 24 weeks gestation was associated with altered kinetics of inflammatory (C-Reactive Protein [CRP], Chitinase 3-like protein-1 [CHI3L1], Interleukin 18 Binding Protein [IL-18BP], soluble Tumor Necrosis Factor receptor II [sTNFRII], soluble Intercellular Adhesion Molecule-1 [sICAM-1]), angiogenic (soluble Endoglin [sEng]), and metabolic mediators (Leptin, Angiopoietin-like 3 [Angptl3]) over the course of pregnancy (χ2 > 13.0, p ≤ 0.001 for each). Limitations include being underpowered to assess the impact on nonviable births, being unable to assess women who had not received any antimalarials, and, because of the exposure to antimalarials in the second trimester, there were limited numbers of malaria infections late in pregnancy. Conclusions Current interventions for the prevention of malaria in pregnancy are initiated at the first antenatal visit, usually in the second trimester. In this study, we found that many women are already malaria-infected by their first visit. Malaria infection before 24 weeks gestation was associated with dysregulation of essential regulators of angiogenesis, metabolism, and inflammation and an increased risk of PTB. Preventing malaria earlier in pregnancy may reduce placental dysfunction and thereby improve birth outcomes in malaria-endemic settings.Item Further Characterization of the Mitigation of Radiation Lethality by Protective Wounding(Radiation Research Society, 2017-06) Dynlacht, Joseph R.; Garrett, Joy; Joel, Rebecca; Lane, Katharina; Mendonca, Marc S.; Orschell, Christie M.; Radiation Oncology, School of MedicineThere continues to be a major effort in the United States to develop mitigators for the treatment of mass casualties that received high-intensity acute ionizing radiation exposures from the detonation of an improvised nuclear device during a radiological terrorist attack. The ideal countermeasure should be effective when administered after exposure, and over a wide range of absorbed doses. We have previously shown that the administration of a subcutaneous incision of a defined length, if administered within minutes after irradiation, protected young adult female C57BL/6 mice against radiation-induced lethality, and increased survival after total-body exposure to an LD50/30 X-ray dose from 50% to over 90%. We refer to this approach as "protective wounding". In this article, we report on our efforts to further optimize, characterize and demonstrate the validity of the protective wounding response by comparing the response of female and male mice, varying the radiation dose, the size of the wound, and the timing of wounding with respect to administration of the radiation dose. Both male and female mice that received a subcutaneous incision after irradiation were significantly protected from radiation lethality. We observed that the extent of protection against lethality after an LD50/30 X-ray dose was independent of the size of the subcutaneous cut, and that a 3 mm subcutaneous incision is effective at enhancing the survival of mice exposed to a broad range of radiation doses (LD15-LD100). Over the range of 6.2-6.7 Gy, the increase in survival observed in mice that received an incision was associated with an enhanced recovery of hematopoiesis. The enhanced rate of recovery of hematopoiesis was preceded by an increase in the production of a select group of cytokines. Thus, a thorough knowledge of the timing of the cytokine cascade after wounding could aid in the development of novel pharmacological radiation countermeasures that can be administered several days after the actual radiation exposure.Item High Survivorship With a Titanium-encased Alumina Ceramic Bearing for Total Hip Arthroplasty(Springer US, 2014-02) D’Antonio, James A.; Capello, William N.; Naughton, Marybeth; Department of Orthopaedic Surgery, IU School of MedicineBackground Although ceramic-on-ceramic bearings for total hip arthroplasty (THA) show promising results in terms of bearing-surface wear, fracture of the bearing, insertional chips, and squeaking remain a concern. Questions/purposes Our primary objective of this report was to determine overall survivorship of a titanium- encased ceramic-on-ceramic bearing couple. Our secondary objectives were to evaluate for ceramic fracture, insertional chips, osteolysis, and device squeaking. Methods Six surgeons at six institutions implanted 194 patients (209 hips) with an average age of 52 years with cementless hips and alumina ceramic bearings. One hun- dred thirty-seven patients (146 hips) have 10-year followup (70%). We determined Kaplan-Meier survivorship of the bearing surface and implant system and collected radio- graphic and clinical data to evaluate for osteolysis and squeaking. Results Survivorship using revision for any reason as the end point was 97% at 10 years and survivorship end point bearing surface failure or aseptic loosening of 99%. There was one ceramic insert fracture (0.5%), there were no insertional chips, there was no visible osteolysis on AP and lateral radiographs, and there was a 1% patient- self-reported incidence of squeaking at the last clinical followup. Six hips underwent revision (3.7%). Conclusions Ceramic bearings for THA with a titanium- encased insert have high survivorship at 10 years followup and a fracture risk of 0.5%. We found at last followup on routine radiographs no evidence of osteolysis, and no patient has been revised for squeaking or has reported dissatisfaction with the clinical result because of noise. Level of Evidence Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.Item Metastatic breast cancer patients' expectations and priorities for symptom improvement(Springer Nature, 2018-11) Tometich, Danielle B.; Mosher, Catherine E.; Hirsh, Adam T.; Rand, Kevin L.; Johns, Shelley A.; Matthias, Marianne S.; Outcalt, Samantha D.; Schneider, Bryan P.; Mina, Lida; Storniolo, Anna Maria V.; Newton, Erin V.; Miller, Kathy D.; Psychology, School of SciencePURPOSE: Little research has examined cancer patients' expectations, goals, and priorities for symptom improvement. Thus, we examined these outcomes in metastatic breast cancer patients to provide patients' perspectives on clinically meaningful symptom improvement and priorities for symptom management. METHODS: Eighty women with metastatic breast cancer participated in a survey with measures of comorbidity, functional status, engagement in roles and activities, distress, quality of life, and the modified Patient-Centered Outcomes Questionnaire that focused on 10 common symptoms in cancer patients. RESULTS: On average, patients reported low to moderate severity across the 10 symptoms and expected symptom treatment to be successful. Patients indicated that a 49% reduction in fatigue, 48% reduction in thinking problems, and 43% reduction in sleep problems would represent successful symptom treatment. Cluster analysis based on ratings of the importance of symptom improvement yielded three clusters of patients: (1) those who rated thinking problems, sleep problems, and fatigue as highly important, (2) those who rated pain as moderately important, and (3) those who rated all symptoms as highly important. The first patient cluster differed from other subgroups in severity of thinking problems and education. CONCLUSIONS: Metastatic breast cancer patients report differing symptom treatment priorities and criteria for treatment success across symptoms. Considering cancer patients' perspectives on clinically meaningful symptom improvement and priorities for symptom management will ensure that treatment is consistent with their values and goals.