Browsing by Subject "Sigmoidal mixed model"

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    The dynamics of cognitive decline toward Alzheimer's disease progression: Results from ADSP‐PHC's harmonized cognitive composites
    (Wiley, 2025) Kang, Kaidi; Zhang, Panpan; Dumitrescu, Logan; Mukherjee, Shubhabrata; Lee, Michael L.; Choi, Seo-Eun; Trittschuh, Emily H.; Mez, Jesse; Saykin, Andrew J.; Gifford, Katherine A.; Buckley, Rachel F.; Gao, Xiaoting; Di, Jianing; Crane, Paul K.; Hohman, Timothy J.; Liu, Dandan; Radiology and Imaging Sciences, School of Medicine
    Introduction: Accurately assessing the temporal order of cognitive decline across multiple domains is critical in Alzheimer's disease (AD). Existing literature presents controversial conclusions likely due to the use of a single cohort and different analytical strategies. Methods: Harmonized composite cognitive measures in memory, language, and executive functions from 13 cohorts in the Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC) were used. A double anchoring events-based sigmoidal mixed model was developed using time to incident AD diagnosis as the time scale. Results: In general, decline in memory occurred before decline in language, followed by decline in executive function. This temporal order generally persisted within each subgroup of apolipoprotein E ε4 carrier status, sex, and race/ethnicity. Discussion: This study demonstrated the use of harmonized data across multiple cohorts to characterize the temporal order of cognitive decline along AD progression. Using time to incident AD diagnosis as the time scale can enhance research reproducibility and clinical practice. Highlights: Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium's harmonized composite cognitive measures from 13 cohort studies fitted with a novel double anchoring event-based sigmoidal mixed model reveal the following temporal order of cognitive decline toward AD progression: memory, language, and executive function. If only investigated using individual cohort studies, the temporal order of cognitive decline would vary due to the underlying heterogeneities across studies. This temporal order generally persisted within each subgroup of apolipoprotein E ε4 carrier status, sex, and race/ethnicity.
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    The Dynamics of Cognitive Decline towards Alzheimer’s Disease Progression: Results from ADSP-PHC’s Harmonized Cognitive Composites
    (medRxiv, 2025-01-06) Kang, Kaidi; Zhang, Panpan; Dumitrescu, Logan; Mukherjee, Shubhabrata; Lee, Michael L.; Choi, Seo-Eun; Trittschuh, Emily H.; Mez, Jesse; Saykin, Andrew J.; Gifford, Katherine A.; Buckley, Rachel F.; Gao, Xiaoting; Di, Jianing; Crane, Paul K.; Hohman, Timothy J.; Liu, Dandan; Radiology and Imaging Sciences, School of Medicine
    Introduction: Accurately assessing temporal order of cognitive decline across multiple domains is critical in Alzheimer's disease (AD). Existing literature presented controversial conclusions likely due to the use of a single cohort and different analytical strategies. Methods: Harmonized composite cognitive measures in memory, language and executive functions from 13 cohorts in the ADSP-PHC data are used. A novel double anchoring events-based sigmoidal mixed model was developed using time to the incident of AD diagnosis as the time scale. Results: Decline in memory occurred before decline in language which was followed by the decline in executive function. Throughout the entire AD continuum, APOE-ε4 non-carriers and non-Hispanic Whites showed better memory performance, respectively, in all three cognitive domains. Discussion: Using harmonized data across multiple cohorts is the key to accurately characterizing the temporal order of AD biomarkers. Time to incident AD diagnosis should be used as the time scale for reproducibility purposes.