Browsing by Subject "Organ transplantation"

Now showing 1 - 4 of 4
  • Thumbnail Image
    Item
    Associations between the stanford integrated psychosocial assessment for transplant and one-year lung transplant medical and psychosocial outcomes
    (Springer Nature, 2023-06-12) Hinton-Froese, Kendra E.; Teh, Lisa; Henderson, Danielle R.; Hage, Chadi A.; Chernyak, Yelena; Psychiatry, School of Medicine
    The Stanford Integrated Psychosocial Assessment for Transplant (SIPAT) is a standardized measure of the psychosocial risk profile of solid organ transplant candidates. While studies have found associations between this measure and transplant outcomes, to date this has not been examined in lung transplant recipients. We examined relations between pre-transplant SIPAT scores and 1-year lung transplant medical and psychosocial outcomes in a sample of 45 lung transplant recipients. The SIPAT was significantly associated with 6-minute walk test (χ2(1) = 6.47, p = .010), number of readmissions (χ2(1) = 6.47, p = .011), and mental health services utilization (χ2(1) = 18.15, p < .001). It was not a significantly associated with the presence of organ rejection or mortality (ps > 0.10). Results suggest that the SIPAT can help identify patients who are at an elevated risk for transplant complications and thus would benefit from services to mitigate risk factors and improve outcomes.
  • Thumbnail Image
    Item
    CHRONIC TRANSPLANT REJECTION: PROBLEMS, DISCOVERIES, SOLUTIONS
    (Office of the Vice Chancellor for Research, 2012-04-13) Aulds-Stier, Mitchell; Su, Eric; Saltagi, Mohamad; Khan, Karim; Ward, Richard; Johnson, Raymond
    Organ transplantation has become an increasingly important remedy in helping extend the lives of patients with organ failures or deficien-cies. Although the survival rates of organ recipients have dramatically increased in the short term (1-5 years), long-term (5+ years) survival rates have not improved significantly. Additionally, increasingly un-healthy lifestyles have contributed to a dramatic increase in the need for organ transplants, while organ supply has only slightly increased, resulting in a constantly increasing gap between organ demand and organ supply. Dr. Raymond Johnson, an IU Health Physician, discov-ered a new T cell subset that is resistant to medications routinely used to prevent transplant rejection. This discovery is important because it can be used to develop mechanism-specific diagnostic blood tests for chronic rejection and, potentially, new drugs to treat chronic trans-plant rejection. However, innovations developed in faculty labs often face multiple hurdles in reaching the market place. As participants in the Innovation-to-Technology Central (ITEC) program, our unique multidisciplinary team of students investigated Dr. Raymond Johnson’s discovery by conducting literature research and expert interviews on organ transplantation and rejection and pharmaceutical drugs used in preventing acute transplant rejection. Through our research and our interviews, we were able to further document the dire need for meth-ods for increasing survival rates of transplanted organs. Most im-portantly, we have conducted preliminary market research and devel-oped several commercialization strategy recommendations based on comparable innovation analysis and precedent biotechnology start-up strategies. We anticipate that our research will provide Dr. Johnson with new information and perspectives to help seek venture capitalists to invest in his research, which holds the promise to change the lives of thousands of transplant recipients each year. Funding provided by IUPUI’s Innovation-to-Enterprise Central (ITEC).
  • Thumbnail Image
    Item
    Deceased donor organ procurement injuries in the United States
    (Baishideng Publishing Group Co (World Journal of Transplantation), 2016-06-24) Taber, Tim E.; Neidlinger, Nikole A.; Mujtaba, Muhammad A.; Eidbo, Elling E.; Cauwels, Roxane L.; Hannan, Elizabeth M.; Miller, Jennifer R.; Paramesh, Anil S.; Department of Medicine, IU School of Medicine
    AIM: To determine the incidence of surgical injury during deceased donor organ procurements. METHODS: Organ damage was classified into three tiers, from 1-3, with the latter rendering the organ non-transplantable. For 12 consecutive months starting in January of 2014, 36 of 58 organ procurement organization's (OPO)'s prospectively submitted quality data regarding organ damage (as reported by the transplanting surgeon and confirmed by the OPO medical director) seen on the procured organ. RESULTS: These 36 OPOs recovered 5401 of the nations's 8504 deceased donors for calendar year 2014. A total of 19043 organs procured were prospectively analyzed. Of this total, 59 organs sustained damage making them non-transplantable (0 intestines; 4 pancreata; 5 lungs; 6 livers; 43 kidneys). The class 3 damage was spread over 22 (of 36) reporting OPO's. CONCLUSION: While damage to the procured organ is rare with organ loss being approximately 0.3% of procured organs, loss of potential transplantable organs does occur during procurement.
  • Thumbnail Image
    Item
    Impact of medical, health related, social and occupational factors on post-liver transplant recovery: a longitudinal study
    (Office of the Vice Chancellor for Research, 2012-04-13) Scott, Patricia J.; Winslow, Emily; Krause, Audrey; Bah, Fatoumata
    Purpose: Organ transplantation is a serious surgery with nearly 10% of patients failing to survive the first three months. Studies of quality of life reflect an increase post-transplant, as compared to pre-transplant, then reports vary including a trend towards decreasing QOL scores by the end of the first transplanted year. In this first year, patients have an increased risk of re-hospitalization due to infection, failure of the body to accept the graft, problems with anti-rejection medications or post- surgical complications. Methods: A longitudinal study of liver transplant recipients (n=23) followed medical, social, and occupational factors, along with SF-36 measures. Results: Variability in QOL scores at 1, 2, 3, 6, 9, and 12 months were directly related to identifiable factors. In those subjects where health returned in an uncomplicated manner, QOL scores consistently improved with the greatest change occurring over the first six months and then tapering off through the end of the first year. Conclusions: These subjects almost uniformly expressed frustration at the length of time it took to return to a healthy state. In circumstances where recovery was delayed due to medical reasons, QOL scores declined significantly until the problems were resolved. In several cases, QOL scores stayed low as these individuals were unprepared for the potential complications associated with this difficult surgery.