IU Indianapolis ScholarWorks :: Browsing by Subject "Nanotechnology"

Browsing by Subject "Nanotechnology"

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2D metal carbides and nitrides (MXenes) for energy storage
(Nature Publishing Group, 2017-01-17) Anasori, Babak; Lukatskaya, Maria R.; Gogotsi, Yury; Mechanical Engineering and Energy, School of Engineering and Technology
The family of 2D transition metal carbides, carbonitrides and nitrides (collectively referred to as MXenes) has expanded rapidly since the discovery of Ti3C2 in 2011. The materials reported so far always have surface terminations, such as hydroxyl, oxygen or fluorine, which impart hydrophilicity to their surfaces. About 20 different MXenes have been synthesized, and the structures and properties of dozens more have been theoretically predicted. The availability of solid solutions, the control of surface terminations and a recent discovery of multi-transition-metal layered MXenes offer the potential for synthesis of many new structures. The versatile chemistry of MXenes allows the tuning of properties for applications including energy storage, electromagnetic interference shielding, reinforcement for composites, water purification, gas- and biosensors, lubrication, and photo-, electro- and chemical catalysis. Attractive electronic, optical, plasmonic and thermoelectric properties have also been shown. In this Review, we present the synthesis, structure and properties of MXenes, as well as their energy storage and related applications, and an outlook for future research.
The archaeal Dps nanocage targets kidney proximal tubules via glomerular filtration
(American Society for Clinical Investigation, 2019-09-03) Uchida, Masaki; Maier, Bernhard; Waghwani, Hitesh Kumar; Selivanovitch, Ekaterina; Pay, S. Louise; Avera, John; Yun, EJun; Sandoval, Ruben M.; Molitoris, Bruce A.; Zollman, Amy; Douglas, Trevor; Hato, Takashi; Medicine, School of Medicine
Nature exploits cage-like proteins for a variety of biological purposes, from molecular packaging and cargo delivery to catalysis. These cage-like proteins are of immense importance in nanomedicine due to their propensity to self-assemble from simple identical building blocks to highly ordered architecture and the design flexibility afforded by protein engineering. However, delivery of protein nanocages to the renal tubules remains a major challenge because of the glomerular filtration barrier, which effectively excludes conventional size nanocages. Here, we show that DNA-binding protein from starved cells (Dps) — the extremely small archaeal antioxidant nanocage — is able to cross the glomerular filtration barrier and is endocytosed by the renal proximal tubules. Using a model of endotoxemia, we present an example of the way in which proximal tubule–selective Dps nanocages can limit the degree of endotoxin-induced kidney injury. This was accomplished by amplifying the endogenous antioxidant property of Dps with addition of a dinuclear manganese cluster. Dps is the first-in-class protein cage nanoparticle that can be targeted to renal proximal tubules through glomerular filtration. In addition to its therapeutic potential, chemical and genetic engineering of Dps will offer a nanoplatform to advance our understanding of the physiology and pathophysiology of glomerular filtration and tubular endocytosis.
Design and Fabrication of High Capacity Lithium-Ion Batteries using Electro-Spun Graphene Modified Vanadium Pentoxide Cathodes
(2019-08) Ahmadian, Amirhossein; Agarwal, Mangilal; Xie, Jian; Dalir, Hamid
Electrospinning has gained immense interests in recent years due to its potential application in various fields, including energy storage application. The V2O5/GO as a layered crystal structure has been demonstrated to fabricate nanofibers with diameters within a range of ~300nm through electrospinning technique. The porous, hollow, and interconnected nanostructures were produced by electrospinning formed by polymers such as Polyvinylpyrrolidone (PVP) and Polyvinyl alcohol (PVA), separately, as solvent polymers with electrospinning technique. In this study, we investigated the synthesis of a graphene-modified nanostructured V2O5 through modified sol-gel method and electrospinning of V2O5/GO hybrid. Electrochemical characterization was performed by utilizing Arbin Battery cycler, Field Emission Scanning Electron Microscopy (FESEM), X-ray powder diffraction (XRD), Thermogravimetric analysis (TGA), Mercury Porosimetry, and BET surface area measurement. As compared to the other conventional fabrication methods, our optimized sol-gel method, followed by the electrospinning of the cathode material achieved a high initial capacity of 342 mAh/g at a high current density of 0.5C (171 mA/g) and the capacity retention of 80% after 20 cycles. Also, the prepared sol-gel method outperforms the pure V2O5 cathode material, by obtaining the capacity almost two times higher. The results of this study showed that post-synthesis treatment of cathode material plays a prominent role in electrochemical performance of the nanostructured vanadium oxides. By controlling the annealing and drying steps, and time, a small amount of pyrolysis carbon can be retained, which improves the conductivity of the V2O5 nanorods. Also, controlled post-synthesis helped us to prevent aggregation of electro-spun twisted nanostructured fibers which deteriorates the lithium diffusion process during charge/discharge of batteries.
Development of an Online 2D Ultrahigh-Pressure Nano-LC System for High-pH and Low-pH Reversed Phase Separation in Top-Down Proteomics
(American Chemical Society, 2020-08-28) Wang, Zhe; Yu, Dahang; Cupp-Sutton, Kellye A.; Liu, Xiaowen; Smith, Kenneth; Wu, Si; Computer and Information Science, School of Science
The development of novel high-resolution separation techniques is crucial for advancing the complex sample analysis necessary for high-throughput top-down proteomics. Recently, our group developed an offline 2D high-pH RPLC/low-pH RPLC separation method and demonstrated good orthogonality between these two RPLC formats. Specifically, ultrahigh-pressure long capillary column RPLC separation has been applied as the second dimensional low-pH RPLC separation for the improvement of separation resolution. To further improve the throughput and sensitivity of the offline approach, we developed an online 2D ultrahigh-pressure nano-LC system for high-pH and low-pH RPLC separations in top-down proteomics. An online microtrap column with a dilution setup was used to collect eluted proteins from the first dimension high-pH separation and inject the fractions for ultrahigh-pressure long capillary column low-pH RPLC separation in the second dimension. This automatic platform enables the characterization of 1000+ intact proteoforms from 5 μg of intact E. coli cell lysate in 10 online-collected fractions. Here, we have demonstrated that our online 2D pH RP/RPLC system coupled with top-down proteomics holds the potential for deep proteome characterization of mass-limited samples because it allows the identification of hundreds of intact proteoforms from complex biological samples at low microgram sample amounts.
Editorial on the Special Issue “Advances in Nanogels”
(MDPI, 2022-12-17) Lin, Chien-Chi; Mauri, Emanuele; Rossi, Filippo; Biomedical Engineering, School of Engineering and Technology
An Evaluation of a Research Experience Traineeship (RET) Program for Integrating Nanotechnology into Pre-College Curriculum
(2017-06-24) Hess, Justin L.; Feldhaus, Charles; P.e, Maher E. Rizkalla; Agarwal, Mangilal; Technology and Leadership Communication, School of Engineering and Technology
Nanotechnology has become a national focus throughout the United States with more than 24 billion USD of cumulative federal support towards nanotechnology research and development since 2001. In the last 20 years, R&D in this space has led to a number of revolutions in electronics, photovoltaics, manufacturing, medicine and much more. One of the primary goals of this federal funding, as described by the inter-governmental body, the Committee on Technology Subcommittee on Nanoscale Science, Engineering, and Technology (NSET), has been to develop educational resources that will ultimately lead to a skilled workforce who will continually advance the state of the art of nanotechnology. This study explores the impact of one summer’s implementation of an NSF-funded Research Experiences for Teachers professional development K-12 program designed towards this end. Specifically, the Research Experiences for Teacher Advancement in Nanotechnology (RETAIN) program at a large public Midwestern University was designed to provide 30 K-12 teachers (10 per year, primarily high school level) from high-needs, urban school districts with research experiences and shared activities designed to increase their understanding of the challenges and demands of nanotechnology, as well as college and career opportunities in science, technology, engineering, and mathematics (STEM) fields. In addition to these research experiences, our multi-disciplinary team sought to lead participants in the creation of 15 hands-on inquiry-based teaching modules (5 per year) that integrate multiple STEM disciplines, convey scientific-process skills, and align with Indiana Academic Standards and the Next Generation Science Standards. We frame this study as research evaluation, as our initial focus was on evaluating programmatic outcomes with the intention of improving the program itself through a cyclical process of research to practice. In this paper, our scope extends to the broader scholarly community: here we build on our evaluation results, with the aim of extending the body of knowledge pertaining to STEM professional development opportunities similar to this one
Investing in the Future Nanos: IUPUI Nanotechnology Discovery Academy
(Office of the Vice Chancellor for Research, 2016-04-08) Mirza, Qurat-ul-Ann; Bondi, Joseph; Sorge, Brandon; Agarwal, Mangilal
Nanotechnology is a rapidly advancing field that is being applied to many aspects of everyday life. Consequently, it has become crucial to increase the general population’s understanding of nanotechnology and its application. To accomplish this, STEMCorp at IUPUI has been assisting INDA with week long summer camps that work to increase high school student’s awareness and understanding of nanotechnology. The camp consists of a morning seminars, afternoon lab activities, lab tour, and end-of-camp poster presentation. Lab tours focus on showing participants the practical applications of nanotechnology and exposes them to nanotechnology research occurring in Indianapolis. Afternoon lab activities immerse the students in a hands-on application of nanotechnology, providing a deeper understanding of the concepts introduced in the morning seminars. To assess the effectiveness of the INDA Nanotechnology summer camp, students were given pre- and post-assessment surveys to measure their interest in, and understanding of nanotechnology and STEM fields. Additionally, groups of students were selected for interviews and focus groups to provide a more in-depth understanding of their experience. From these data, it was found that the summer camp was effective at increasing student’s interest in and understanding of nanotechnology. Additionally, the student interviews/focus groups identified crucial components to this success.
Material design using surrogate optimization algorithm
(2015-02-28) Khadke, Kunal R.; Tovar, Andrés; Zhu, Likun; El-Mounayri, Hazim
Nanocomposite ceramics have been widely studied in order to tailor desired properties at high temperatures. Methodologies for development of material design are still under effect. While finite element modeling (FEM) provides significant insight on material behavior, few design researchers have addressed the design paradox that accompanies this rapid design space expansion. A surrogate optimization model management framework has been proposed to make this design process tractable. In the surrogate optimization material design tool, the analysis cost is reduced by performing simulations on the surrogate model instead of high fidelity finite element model. The methodology is incorporated to and the optimal number of silicon carbide (SiC) particles, in a silicon-nitride(Si3N4) composite with maximum fracture energy [2]. Along with a deterministic optimization algorithm, model uncertainties have also been considered with the use of robust design optimization (RDO) method ensuring a design of minimum sensitivity to changes in the parameters. These methodologies applied to nanocomposites design have a significant impact on cost and design cycle time reduced.
Modeling and design optimization of a microfluidic chip for isolation of rare cells
(2013-12) Gannavaram, Spandana; Zhu, Likun; Yu, Huidan (Whitney); Xie, Jian; Anwar, Sohel
Cancer is still among those diseases that prominently contribute to the numerous deaths that are caused each year. But as technology and research is reaching new zeniths in the present times, cure or early detection of cancer is possible. The detection of rare cells can help understand the origin of many diseases. The current study deals with one such technology that is used for the capture or effective separation of these rare cells called Lab-on-a-chip microchip technology. The isolation and capture of rare cells is a problem uniquely suited to microfluidic devices, in which geometries on the cellular length scale can be engineered and a wide range of chemical functionalizations can be implemented. The performance of such devices is primarily affected by the chemical interaction between the cell and the capture surface and the mechanics of cell-surface collision and adhesion. This study focuses on the fundamental adhesion and transport mechanisms in rare cell-capture microdevices, and explores modern device design strategies in a transport context. The biorheology and engineering parameters of cell adhesion are defined; chip geometries are reviewed. Transport at the microscale, cell-wall interactions that result in cell motion across streamlines, is discussed. We have concentrated majorly on the fluid dynamics design of the chip. A simplified description of the device would be to say that the chip is at micro scale. There are posts arranged on the chip such that the arrangement will lead to a higher capture of rare cells. Blood consisting of rare cells will be passed through the chip and the posts will pose as an obstruction so that the interception and capture efficiency of the rare cells increases. The captured cells can be observed by fluorescence microscopy. As compared to previous studies of using solid microposts, we will be incorporating a new concept of cylindrical shell micropost. This type of micropost consists of a solid inner core and the annulus area is covered with a forest of silicon nanopillars. Utilization of such a design helps in increasing the interception and capture efficiency and reducing the hydrodynamic resistance between the cells and the posts. Computational analysis is done for different designs of the posts. Drag on the microposts due to fluid flow has a great significance on the capture efficiency of the chip. Also, the arrangement of the posts is important to contributing to the increase in the interception efficiency. The effects of these parameters on the efficiency in junction with other factors have been studied and quantified. The study is concluded by discussing design strategies with a focus on leveraging the underlying transport phenomena to maximize device performance.
Multi-scale analysis of morphology, mechanics, and composition of collagen in murine osteogenesis imperfecta
(2013-11-06) Bart, Zachary Ryan; Wallace, Joseph; Na, Sungsoo; Yokota, Hiroki, 1955-; Schild, John H.
Osteogenesis imperfecta is a rare congenital disease commonly characterized by brittle bones caused by mutations in the genes encoding Type I collagen, the single most abundant protein produced by the body. The murine model (oim) exists as a natural mutation of this protein, converting its heterotrimeric structure of two Col1a1 molecules and a single Col1a2 molecule into homotrimers composed of only the former. This defect impacts bone mechanical integrity, greatly weakening their structure. Femurs from male wild type (WT), heterozygous (oim/+), and homozygous (oim/oim) mice, all at 12 weeks of age, were assessed using assays at multiple length scales with minimal sample processing to ensure a near-physiological state. Atomic force microscopy (AFM) demonstrated detectable differences in the organization of collagen at the nanometer scale that may partially attribute to alterations in material and structural behavior obtained through mechanical testing and reference point indentation (RPI). Changes in geometric and chemical structure through the use of µ-Computed Tomography and Raman spectroscopy respectively indicate a smaller, brittle phenotype caused by oim. Changes within the periodic D-spacing of collagen point towards a reduced mineral nucleation site, supported by reduced mineral crystallinity, resulting in altered material and structural behavior in oim/oim mice. Multi-scale analyses of this nature offer much in assessing how molecular changes can compound to create a degraded, brittle phenotype.

Browsing by Subject "Nanotechnology"

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