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Item The 1st International Joint Mini-Symposium on Advanced Coatings between Indiana University-Purdue University Indianapolis and Changwon National University: Preface(2014) Zhang, Jing; Jung, Yeon-GilThe 1st international joint mini-symposium on advanced coatings between Indiana University-Purdue University Indianapolis (IUPUI) and Changwon National University (CNU) was held on March 18-20, 2014 in Indianapolis, Indiana, USA. Research papers presented in the symposium are included in this proceeding. The symposium covered recent development in advanced coatings and related functional materials. The symposium offered the students and researchers from both universities a valuable opportunity to share a wide spectrum of new knowledge of advanced coatings and related functional materials. The research topics presented in the symposium included thermal barrier coatings, bio-related coatings, nano-materials and materials for energy conversion. The symposium enabled face-to-face discussions and developed genuine friendship, which promoted international collaboration and exchange program for researcher as well as students to carry out science work together. J.Z. would like to thank the support provided by the US Department of Energy (Grant No. DE-FE0008868, program manager Richard Dunst) and International Development Fund by the IUPUI Office of Vice Chancellor for Research. Y.G.J. acknowledges the support provided by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP) (No. 2011-0030058) and the Human Resources Development Program (No. 20134030200220) of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Korean Government Ministry of Trade, Industry and Energy.Item 3D Printed ABS and Carbon Fiber Reinforced Polymer Specimens for Engineering Education(Springer, 2016) Golub, Michael; Guo, Xingye; Jung, Mingyo; Zhang, Jing; Department of Mechanical Engineering, School of Engineering and TechnologyThree 3D printed plastic materials, ABS, ABS plus, and CFRP, have been studied for their potential applications in engineering education. Using tensile test, the stress strain curves of the materials have been measured. The Young’s modulus, ultimate strength, and fracture toughness of the materials are calculated from the stress strain curve. The results show that CFRP has the highest stiffness or Young’s modulus. ABS plus has strongest mechanical properties, with highest ultimate strength and fracture toughness. With the measured properties, the 3D printed samples are a viable solution for engineering students to learn mechanical properties of materials.Item A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8(eLife Sciences, 2022-12-14) Tarasov, Kirill V.; Chakir, Khalid; Riordon, Daniel R.; Lyashkov, Alexey E.; Ahmet, Ismayil; Perino, Maria Grazia; Silvester, Allwin Jennifa; Zhang, Jing; Wang, Mingyi; Lukyanenko, Yevgeniya O.; Qu, Jia-Hua; Barrera, Miguel Calvo-Rubio; Juhaszova, Magdalena; Tarasova, Yelena S.; Ziman, Bruce; Telljohann, Richard; Kumar, Vikas; Ranek, Mark; Lammons, John; Bychkov, Rostislav; de Cabo, Rafael; Jun, Seungho; Keceli, Gizem; Gupta, Ashish; Yang, Dongmei; Aon, Miguel A.; Adamo, Luigi; Morrell, Christopher H.; Otu, Walter; Carroll, Cameron; Chambers, Shane; Paolocci, Nazareno; Huynh, Thanh; Pacak, Karel; Weiss, Robert; Field, Loren; Sollott, Steven J.; Lakatta, Edward G.; Medicine, School of MedicineAdult (3 month) mice with cardiac-specific overexpression of adenylyl cyclase (AC) type VIII (TGAC8) adapt to an increased cAMP-induced cardiac workload (~30% increases in heart rate, ejection fraction and cardiac output) for up to a year without signs of heart failure or excessive mortality. Here, we show classical cardiac hypertrophy markers were absent in TGAC8, and that total left ventricular (LV) mass was not increased: a reduced LV cavity volume in TGAC8 was encased by thicker LV walls harboring an increased number of small cardiac myocytes, and a network of small interstitial proliferative non-cardiac myocytes compared to wild type (WT) littermates; Protein synthesis, proteosome activity, and autophagy were enhanced in TGAC8 vs WT, and Nrf-2, Hsp90α, and ACC2 protein levels were increased. Despite increased energy demands in vivo LV ATP and phosphocreatine levels in TGAC8 did not differ from WT. Unbiased omics analyses identified more than 2,000 transcripts and proteins, comprising a broad array of biological processes across multiple cellular compartments, which differed by genotype; compared to WT, in TGAC8 there was a shift from fatty acid oxidation to aerobic glycolysis in the context of increased utilization of the pentose phosphate shunt and nucleotide synthesis. Thus, marked overexpression of AC8 engages complex, coordinate adaptation "circuity" that has evolved in mammalian cells to defend against stress that threatens health or life (elements of which have already been shown to be central to cardiac ischemic pre-conditioning and exercise endurance cardiac conditioning) that may be of biological significance to allow for proper healing in disease states such as infarction or failure of the heart.Item Ab initio study of anisotropic mechanical properties of LiCoO2 during lithium intercalation and deintercalation process(Office of the Vice Chancellor for Research, 2016-04-08) Wu, Linmin; Zhang, JingThe mechanical properties of LixCoO2 under various Li concentrations and associated anisotropy have been systematically studied using the first principles method. During the lithium intercalation process, the Young's modulus, bulk modulus, shear modulus, and ultimate strength increase with increasing lithium concentration. Strong anisotropy of mechanical properties between a-axis and c-axis in LixCoO2 is identified at low lithium concentrations, and the anisotropy decreases with increasing lithium concentration. The observed lithium concentration dependence and anisotropy are explained by analyzing the charge transfer using Bader charge analysis, bond order analysis, and bond strength by investigating partial density of states and charge density difference. With the decrease of Li concentration, the charge depletion in the bonding regions increases, indicating a weaker Co-O bond strength. Additionally, the Young's modulus, bulk modulus, shear modulus, and toughness are obtained by simulating ab initio tensile tests. From the simulated stress-strain curves, LixCoO2 shows the highest toughness, which is in contraction with Pugh criterion prediction based on elastic properties only.Item Ab initio study of anisotropic mechanical properties of LiCoO2 during lithium intercalation and deintercalation process(AIP, 2015-12) Wu, Linmin; Zhang, Jing; Department of Mechanical Engineering, School of Engineering and TechnologyThe mechanical properties of LixCoO2 under various Li concentrations and associated anisotropy have been systematically studied using the first principles method. During the lithium intercalation process, the Young's modulus,bulk modulus,shear modulus, and ultimate strength increase with increasing lithium concentration. Strong anisotropy of mechanical properties between a-axis and c-axis in LixCoO2 is identified at low lithium concentrations, and the anisotropy decreases with increasing lithium concentration. The observed lithium concentration dependence and anisotropy are explained by analyzing the charge transfer using Bader charge analysis, bond order analysis, and bond strength by investigating partial density of states and charge density difference. With the decrease of Li concentration, the charge depletion in the bonding regions increases, indicating a weaker Co-O bond strength. Additionally, the Young's modulus,bulk modulus,shear modulus, and toughness are obtained by simulating ab initio tensile tests. From the simulated stress-strain curves, LixCoO2 shows the highest toughness, which is in contraction with Pugh criterion prediction based on elastic properties only.Item Abrasive Resistant Coatings—A Review(MDPI, 2014-05-21) Wu, Linmin; Guo, Xingye; Zhang, Jing; Mechanical Engineering, School of Engineering and TechnologyAbrasive resistant coatings have been widely used to reduce or eliminate wear, extending the lifetime of products. Abrasive resistant coatings can also be used in certain environments unsuitable for lubrications. Moreover, abrasive resistant coatings have been employed to strengthen mechanical properties, such as hardness and toughness. Given recently rapid development in abrasive resistant coatings, this paper provides a review of major types of abrasive coatings, their wearing mechanisms, preparation methods, and properties.Item The actin-related p41ARC subunit contributes to p21-activated kinase-1 (PAK1)-mediated glucose uptake into skeletal muscle cells(American Society for Biochemistry and Molecular Biology, 2017-11-17) Tunduguru, Ragadeepthi; Zhang, Jing; Aslamy, Arianne; Salunkhe, Vishal A.; Brozinick, Joseph T.; Elmendorf, Jeffrey S.; Thurmond, Debbie C.; Biochemistry and Molecular Biology, School of MedicineDefects in translocation of the glucose transporter GLUT4 are associated with peripheral insulin resistance, preclinical diabetes, and progression to type 2 diabetes. GLUT4 recruitment to the plasma membrane of skeletal muscle cells requires F-actin remodeling. Insulin signaling in muscle requires p21-activated kinase-1 (PAK1), whose downstream signaling triggers actin remodeling, which promotes GLUT4 vesicle translocation and glucose uptake into skeletal muscle cells. Actin remodeling is a cyclic process, and although PAK1 is known to initiate changes to the cortical actin-binding protein cofilin to stimulate the depolymerizing arm of the cycle, how PAK1 might trigger the polymerizing arm of the cycle remains unresolved. Toward this, we investigated whether PAK1 contributes to the mechanisms involving the actin-binding and -polymerizing proteins neural Wiskott-Aldrich syndrome protein (N-WASP), cortactin, and ARP2/3 subunits. We found that the actin-polymerizing ARP2/3 subunit p41ARC is a PAK1 substrate in skeletal muscle cells. Moreover, co-immunoprecipitation experiments revealed that insulin stimulates p41ARC phosphorylation and increases its association with N-WASP coordinately with the associations of N-WASP with cortactin and actin. Importantly, all of these associations were ablated by the PAK inhibitor IPA3, suggesting that PAK1 activation lies upstream of these actin-polymerizing complexes. Using the N-WASP inhibitor wiskostatin, we further demonstrated that N-WASP is required for localized F-actin polymerization, GLUT4 vesicle translocation, and glucose uptake. These results expand the model of insulin-stimulated glucose uptake in skeletal muscle cells by implicating p41ARC as a new component of the insulin-signaling cascade and connecting PAK1 signaling to N-WASP-cortactin-mediated actin polymerization and GLUT4 vesicle translocation.Item Additive Manufacturing of Metallic Materials: A Review(Springer, 2017) Zhang, Yi; Wu, Linmin; Guo, Xingye; Kane, Stephen; Deng, Yifan; Jung, Yeon-Gil; Lee, Je-Hyun; Zhang, Jing; Mechanical Engineering, School of Engineering and TechnologyIn this review article, the latest developments of the four most common additive manufacturing methods for metallic materials are reviewed, including powder bed fusion, direct energy deposition, binder jetting, and sheet lamination. In addition to the process principles, the microstructures and mechanical properties of AM-fabricated parts are comprehensively compared and evaluated. Finally, several future research directions are suggested.Item Advanced Silicate-based Lubricant Additive Induced Diamond-like Carbon Structured Restoration Layer(Elsevier, 2015-10) Zhang, Jing; Gu, Yanhong; Liu, Jiajun; Department of Mechanical Engineering, School of EngineeringAn advanced silicate based lubricant additive has been employed in long-term pin-on-disk tribological experiments. The worn steel/steel surfaces were characterized using nano-indentation, SEM, XPS, and Raman spectroscopy for their physical, mechanical, and chemical properties. The average nano-hardness of the repaired layers on the disk and the pin is 10.2 GPa and 16.7 GPa respectively, which is substantially higher than that of the disk (HV 221, or 0.71 GPa) and the pin (HRC55, or 1.8 GPa) before tribological tests, forming super hard surfaces on the contact pair surfaces. Combined Raman spectroscopy and XPS studies suggest the formation of diamond-like carbon based restoration layers. A new formation mechanism of the restoration DLC layer contributing to hard and smooth contact surfaces is proposed.Item Analysis of Process Induced Shape Deformations and Residual Stresses in Composite Parts during Cure(2019-05) Patil, Ameya S.; Dalir, Hamid; El-Mounayri, Hazim; Zhang, JingProcess induced dimensional changes in composite parts has been the topic of interest for many researchers. The residual stresses that are induced in composite laminates during curing process while the laminate is in contact with the process tool often lead to dimensional variations such as spring-in of angles and warpage of flat panels. The traditional trial-and-error approach can work for simple geometries, but composite parts with complex shapes require more sophisticated models. When composite laminates are subjected to thermal stresses, such as the heating and cooling processes during curing, they can become distorted as the in-plane and the throughthickness coeffcients of thermal expansion are di erent, as well as chemical shrinkage of the resin, usually cause spring-in. Deformed components can cause problems during assembly, which significantly increases production costs and affects performance. This thesis focuses on predicting these shape deformations using software simulation of composite manufacturing and curing. Various factors such as resin shrinkage, degrees of cure, difference between through thickness coeffcient of thermal expansion of the composite laminate are taken into the consideration. A cure kinetic model is presented which illustrates the matrix behavior during cure. The results obtained using the software then were compared with the experimental values of spring-in from the available literature. The accuracy of ACCS package was validated in this study. Analyzing the effects of various parameters of it was estimated that 3D part simulation is an effective and cost and time saving method to predict nal shape of the composite part.