Browsing by Author "Renbarger, J."
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Item 70: Defibrotide for the treatment of Sinusoidal Obstruction Syndrome (SOS) following hematopoietic stem cell transplant in pediatric patients(Elsevier, 2007-02-01) Hill, A.B.; Robertson, K.A.; Gowan, D.J.; Lorch, C.; Collura, J.M.; Renbarger, J.; Goebel, W.S.; Haut, P.P.; Medicine, School of MedicineItem IODNE: An integrated optimization method for identifying the deregulated subnetwork for precision medicine in cancer(Wiley, 2017-03) Renbarger, J.; Radovich, M.; Vasudevaraja, V.; Kinnebrew, G.H.; Zhang, S.; Cheng, L.; Inavolu Mounika, S.; Department of Biohealth Informatics, School of Informatics and ComputingSubnetwork analysis can explore complex patterns of entire molecular pathways for the purpose of drug target identification. In this article, the gene expression profiles of a cohort of patients with breast cancer are integrated with protein-protein interaction (PPI) networks using, simultaneously, both edge scoring and node scoring. A novel optimization algorithm, integrated optimization method to identify deregulated subnetwork (IODNE), is developed to search for the optimal dysregulated subnetwork of the merged gene and protein network. IODNE is applied to select subnetworks for Luminal-A breast cancer from The Cancer Genome Atlas (TCGA) data. A large fraction of cancer-related genes and the well-known clinical targets, ER1/PR and HER2, are found by IODNE. This validates the utility of IODNE. When applying IODNE to the triple-negative breast cancer (TNBC) subtype data, we identified subnetworks that contain genes such as ERBB2, HRAS, PGR, CAD, POLE, and SLC2A1.Item Mobilization of peripheral blood CD34 stem cells in a heavily pre-treated pediatric medulloblastoma patient using AMD3100 and G-CSF(Elsevier, 2006-02-01) Robertson, K. A.; Pradhan, K.; Goebel, S.; Renbarger, J.; Abonour, R.; Calandra, G. B.; McFarland, R. T.; Haut, P. R.; Pediatrics, School of Medicine