Browsing by Author "Peterson-Carmichael, Stacey"

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    Lung clearance index in children with sickle cell disease
    (Wiley, 2021-05) Machogu, Evans M.; Khurana, Monica; Kaericher, Jennifer; Clem, Charles C.; Slaven, James E.; Hatch, Joseph E.; Davis, Stephanie D.; Peterson-Carmichael, Stacey; Pediatrics, School of Medicine
    Introduction The lung clearance index (LCI) derived from the multiple breath washout test (MBW), is both feasible and sensitive to early lung disease detection in young children with cystic fibrosis and asthma. The utility of LCI has not been studied in children with sickle cell disease (SCD). We hypothesized that children with SCD, with or without asthma or airway hyperreactivity (AHR), would have an elevated LCI compared to healthy controls. Methods Children with SCD from a single center between the ages of 6 and 18 years were studied at baseline health and completed MBW, spirometry, plethysmography and blood was drawn for serum markers. Results were compared to healthy controls of similar race, age, and gender. Results Healthy controls (n = 35) had a significantly higher daytime oxygen saturation level, weight and body mass index but not height compared to participants with SCD (n = 34). Total lung capacity (TLC) z-scores were significantly higher in the healthy controls compared to those with SCD (0.87 [1.13] vs. 0.02 [1.27]; p = .005) while differences in forced expiratory volume in 1 s z-scores approached significance (0.26 [0.97] vs. −0.22 [1.09]; p = .055). There was no significant difference in LCI between the healthy controls compared to participants with SCD (7.29 [0.72] vs. 7.40 [0.69]; p = .514). Conclusion LCI did not differentiate SCD from healthy controls in children between the ages of 6 and 18 years at baseline health. TLC may be an important pulmonary function measure to follow longitudinally in the pediatric SCD population.
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    Structure and Functions of Pediatric Aerodigestive Programs: A Consensus Statement
    (AAP, 2018-03) Boesch, R. Paul; Balakrishnan, Karthik; Acra, Sari; Benscoter, Dan T.; Cofer, Shelagh A.; Collaco, Joseph M.; Dahl, John P.; Daines, Cori L.; DeAlarcon, Alessandro; DeBoer, Emily M.; Deterding, Robin R.; Friedlander, Joel A.; Gold, Benjamin D.; Grothe, Rayna M.; Hart, Catherine K.; Kazachkov, Mikhail; Lefton-Greif, Maureen A.; Miller, Claire Kane; Moore, Paul E.; Pentiuk, Scott; Peterson-Carmichael, Stacey; Piccione, Joseph; Prager, Jeremy D.; Putnam, Philip E.; Rosen, Rachel; Rutter, Michael J.; Ryan, Matthew J.; Skinner, Margaret L.; Torres-Silva, Cherie; Wootten, Christopher T.; Zur, Karen B.; Cotton, Robin T.; Wood, Robert E.; Pediatrics, School of Medicine
    Aerodigestive programs provide coordinated interdisciplinary care to pediatric patients with complex congenital or acquired conditions affecting breathing, swallowing, and growth. Although there has been a proliferation of programs, as well as national meetings, interest groups and early research activity, there is, as of yet, no consensus definition of an aerodigestive patient, standardized structure, and functions of an aerodigestive program or a blueprint for research prioritization. The Delphi method was used by a multidisciplinary and multi-institutional panel of aerodigestive providers to obtain consensus on 4 broad content areas related to aerodigestive care: (1) definition of an aerodigestive patient, (2) essential construct and functions of an aerodigestive program, (3) identification of aerodigestive research priorities, and (4) evaluation and recognition of aerodigestive programs and future directions. After 3 iterations of survey, consensus was obtained by either a supermajority of 75% or stability in median ranking on 33 of 36 items. This included a standard definition of an aerodigestive patient, level of participation of specific pediatric disciplines in a program, essential components of the care cycle and functions of the program, feeding and swallowing assessment and therapy, procedural scope and volume, research priorities and outcome measures, certification, coding, and funding. We propose the first consensus definition of the aerodigestive care model with specific recommendations regarding associated personnel, infrastructure, research, and outcome measures. We hope that this may provide an initial framework to further standardize care, develop clinical guidelines, and improve outcomes for aerodigestive patients.