Browsing by Author "Kloner, Robert A."

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    (Wiley, 2012) Phillips, Robert A.; Kloner, Robert A.; Grimm, Richard H., Jr.; Weinberger, Myron; Medicine, School of Medicine
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    The Effects of Amlodipine Compared to Losartan in Patients With Mild to Moderately Severe Hypertension
    (Wiley, 2003) Phillips, Robert A.; Kloner, Robert A.; Grimm, Richard H., Jr.; Weinberger, Myron; Medicine, School of Medicine
    The calcium channel blocker amlodipine and angiotensin II receptor blocker losartan, with or without hydrochlorothiazide (HCTZ), were compared for the treatment of mild to moderate hypertension in a multicenter, double-blind, parallel-group clinical trial. Following a 2-week placebo run-in, 440 adults (45-80 years old) were randomized to receive either amlodipine 5 mg once daily or losartan 50 mg once daily. Patients who failed to meet the sitting diastolic blood pressure (BP) reduction goal of
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    Reperfused Myocardial Infarction: The Road to CCS Classification of Acute MI and Beyond
    (Elsevier, 2025) Dharmakumar, Rohan; Kloner, Robert A.; Fishbein, Michael; Heusch, Gerd; Vora, Keyur P.; Gropler, Robert; Henry, Timothy; Shing-Chan, Fai; Singh, Dhirendra; Jambunathan, Nithya; Subramanian, Ramesh; Kreutz, Rolf P.; Reed, Grant W.; Kovacs, Richard J.; Fry, Edward; Kalra, Ankur; Kumar, Andreas; Raman, Subha V.; Medicine, School of Medicine
    The Canadian Cardiovascular Society recently put forth a new classification of acute reperfused myocardial infarction (MI) based on stages of myocardial injury. Backed by more than 5 decades of intense investigation in the field, the key message of this new classification is that not all MIs are the same and that the type and extent of myocardial injury should be considered in diagnosing and treating MI. We review the literature with the goal of highlighting the progressive advances that enabled the synthesis of the Canadian Cardiovascular Society classification into 4 distinct stages of tissue injury. We emphasize the major breakthroughs from insights gained from experimental, translational, and clinical studies to date. We also identify current gaps in knowledge and critical research directions that need to be pursued to improve patient care and reduce post-MI complications such as chronic heart failure and malignant arrhythmias, whose risk is linked to stage and extent of myocardial injury.