Browsing by Author "Khan, Abdul Karim"

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    Analytical Comparison of the Effectiveness of the Diabetes Prevention Program and Weight Watchers as media to prevent Type II Diabetes via Weight Loss in Different Age Categories
    (Office of the Vice Chancellor for Research, 2014-04-11) Khan, Abdul Karim; Palmer, Kelly Nicole Brunson; Marrero, David G.
    Type II Diabetes is a condition in which the body does not utilize insulin properly and causes detrimental symptoms such as glucose build up in the blood, overflown into the urine and passed out of the body without fulfilling the body’s main source of fuel. The Diabetes Prevention Program (DPP) is a multi-center clinical research study aimed to discover modest weight loss methods compared to oral medication (Glucophage) which prevents diabetes. Subsequently, the Health Information and Translational Sciences department at Indiana University School of Medicine uses Weight Watchers, a weight loss program, for participants at risk for Type II Diabetes (pre-diabetic) to monitor their weight and glucose levels. Both programs are investigating ways to justify the same hypothesis using different methods. Both studies aspire to determine the most affective ways for people to lose weight in order to prevent Type II Diabetes. The DPP was an efficacy trial to establish a correlation between weight loss and the risk of Type II Diabetes. Although the DPP successfully proved their hypothesis, the Weight Watchers study provides another approach in the mission of diabetes prevention. By analyzing six months of archived physical measurements data for the Diabetes Prevention Program study and the Weight Watchers study, one can determine how affective each program is in preventing weight loss depending on the age classification. The age groups are compared in fifteen-year intervals for both programs. Although both programs are successful in their mission, the conclusion of which program is more affective is still under continued study.
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    Cleft Lip and Palate Literature Review Compilation
    (Office of the Vice Chancellor for Research, 2015-04-17) Khan, Abdul Karim; Yard, Michael
    The purpose of this review is to provide a summary of the cleft lip or palate procedure with a focus on human anatomy and physiology. Cleft lip and palate are the most common facial malformations and occur in 1 newborn in 2500 live births. Through a thorough analysis of journal articles and viable sources one can grasp an introductory understanding of cleft palate including the history, anatomy, causes, procedure, and post-operation lifestyle with cleft palate. Although the problem is genetic and embryological in nature, anatomy is relevant as the complications stem from oropharyngeal muscles inserting on structural bones, impacting neurovascular areas of the mouth, leading to a complex deformity. The topic was subdivided to cover all areas relevant to the review. The sources used were primarily from journal articles such as PubMed, books, and other online published data. Overall the topic is closely related to medicine and dentistry while incorporating basic anatomical concepts.
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    Selective Bacteriophage Screening Targeting GαqQ209L Protein
    (Office of the Vice Chancellor for Research, 2013-04-05) Khan, Abdul Karim; Sishtila, Kamakshi; Corson, Timothy W.
    Uveal melanoma is the most common intraocular cancer in adults with 2,500 patients diagnosed every year in the United States The cancer is highly chemoersistant and is able to metastasize to other parts of the body, usually the liver where it proves almost universally fatal. It is often difficult to detect the growth of the tumor without a confirmatory biopsy. The goal of this project is to find a peptide sequence specifically binding to GαqQ209l which is an oncogenic mutation causing uveal melanoma in majority of all oncogenic cases. The method of bacteriophage display was used to find a peptide ligand that will bind specifically to the Gαq Q209L; subtractive panning was used against Gαq Wild Type and glutathion. The binders were amplified and then tested using a phage ELISA. This experiment is still in progress and there are no conclusions to be made yet. In the future it is hoped to successfully find a peptide sequence that is specific to cells.