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Browsing by Author "Johnson, Ben"

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    Healthcare Resource Use Associated With Tumor-Induced Osteomalacia: A Literature Review
    (Oxford University Press, 2024) Jan de Beur, Suzanne M.; Dahir, Kathryn M.; Imel, Erik A.; Zanchetta, María Belén; Williams, Angela; Li, Zhiyi; Webb, Neil; Crowe, Victoria; Johnson, Ben; Carpenter, Thomas O.; Medicine, School of Medicine
    Context: Tumor-induced osteomalacia (TIO) is an ultra-rare, paraneoplastic syndrome caused by tumors that secrete fibroblast growth factor 23 (FGF23). Initial signs and musculoskeletal symptoms can be nonspecific and unrecognized, leading to long delays in diagnosis and treatment, and resulting in severe and progressive disability in patients with TIO. Objective: This review aimed to identify published evidence on healthcare resource use in TIO to better understand the burden of the disease. Evidence acquisition: A targeted literature review was conducted to identify publications reporting on disease characteristics and healthcare resource use associated with TIO. Evidence synthesis: In total, 414 publications were included in the review, of which 376 were case reports. From the case reports, data on 621 patients were extracted. These patients had a mean (SD) age of 46.3 (15.8) years; 57.6% were male. Mean time from first symptoms to diagnosis of TIO was 4.6 (4.7) years and, in cases where imaging tests were reported, patients underwent a mean of 4.1 (2.7) procedures. Tumor resection was attempted in 81.0% of patients and successful in 67.0%. Fracture was reported in 49.3% of patients. Results from association analyses demonstrated that longer time to diagnosis was associated with poorer tumor resection outcomes and a higher probability of tumor recurrence. Unfavorable tumor resection outcomes were associated with greater use of pharmacologic treatment and a greater likelihood of orthopedic surgery. Conclusion: TIO is associated with a substantial healthcare resource burden. Improvements in the diagnostic process could lead to better management of TIO, thereby benefiting patients and reducing that burden.
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    Innovative Skills Development in Medical Students Through Neonatal Intubation Solutions​
    (2025-04-25) Russell III, Carl; Patel, Neal; Wilson, Damen; Johnson, Ben; Sivaprakasam, Andrew; Earl, Conner; Conlon, Steven
    Introduction/Background: Modern medical education is widely acknowledged for its rigor and fast pace. With a vast amount of information to absorb and apply, the focus often leans heavily on memorization and clinical proficiency. However, one aspect that is often underemphasized is the discovery of unmet needs and the development of innovative solutions to address these gaps. The Advancing Innovation in Medicine Student Interest Group (AIM SIG) serves as a platform for students to actively engage in identifying and addressing these needs. Study Objective/Hypothesis: The AIM SIG aims to foster innovative, collaborative solutions to systemic healthcare challenges. This year’s focus was the improvement of neonatal intubation techniques through novel equipment. Methods: In collaboration with Dr. Steven Conlon, a neonatologist at Riley Hospital for Children, AIM SIG members participated in a structured, stepwise process to explore and address gaps in neonatal intubation procedures. This process included both experiential learning and hands-on education in the engineering design process, offering medical students exposure to device development. Results: AIM SIG members conducted an extensive review of existing literature, intellectual property, and procedural data, culminating in a comprehensive needs assessment. Furthermore, members learned essential skills in “pretotyping” and 3D modeling, equipping them to generate proof-of-concept solutions aimed at improving neonatal intubation procedures. Conclusions: AIM SIG provides medical students with valuable opportunities to acquire skills in problem-solving and innovation. While translating these innovations into practice presents challenges and setbacks, the experience equips students with a versatile framework to address future problems they may encounter in their medical careers.
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