Browsing by Author "Grimm, Richard H., Jr."

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    (Wiley, 2012) Phillips, Robert A.; Kloner, Robert A.; Grimm, Richard H., Jr.; Weinberger, Myron; Medicine, School of Medicine
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    The Effects of Amlodipine Compared to Losartan in Patients With Mild to Moderately Severe Hypertension
    (Wiley, 2003) Phillips, Robert A.; Kloner, Robert A.; Grimm, Richard H., Jr.; Weinberger, Myron; Medicine, School of Medicine
    The calcium channel blocker amlodipine and angiotensin II receptor blocker losartan, with or without hydrochlorothiazide (HCTZ), were compared for the treatment of mild to moderate hypertension in a multicenter, double-blind, parallel-group clinical trial. Following a 2-week placebo run-in, 440 adults (45-80 years old) were randomized to receive either amlodipine 5 mg once daily or losartan 50 mg once daily. Patients who failed to meet the sitting diastolic blood pressure (BP) reduction goal of