Browsing by Author "Gao, Shan"

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    Parkinson‐like early autonomic dysfunction induced by vagal application of DOPAL in rats
    (Wiley, 2021) Sun, Jie; He, Chao; Yan, Qiu-Xin; Wang, Hong-Dan; Li, Ke-Xin; Sun, Xun; Feng, Yan; Zha, Rong-Rong; Cui, Chang-Peng; Xiong, Xue; Gao, Shan; Wang, Xue; Yin, Rui-Xue; Qiao, Guo-Fen; Li, Bai-Yan; Biomedical Engineering, School of Engineering and Technology
    Aim: To understand why autonomic failures, a common non-motor symptom of Parkinson's disease (PD), occur earlier than typical motor disorders. Methods: Vagal application of DOPAL (3,4-dihydroxyphenylacetaldehyde) to simulate PD-like autonomic dysfunction and understand the connection between PD and cardiovascular dysfunction. Molecular and morphological approaches were employed to test the time-dependent alternation of α-synuclein aggregation and the ultrastructure changes in the heart and nodose (NG)/nucleus tractus solitarius (NTS). Results: Blood pressure (BP) and baroreflex sensitivity of DOPAL-treated rats were significantly reduced accompanied with a time-dependent change in orthostatic BP, consistent with altered echocardiography and cardiomyocyte mitochondrial ultrastructure. Notably, time-dependent and collaborated changes in Mon-/Tri-α-synuclein were paralleled with morphological alternation in the NG and NTS. Conclusion: These all demonstrate that early autonomic dysfunction mediated by vagal application of DOPAL highly suggests the plausible etiology of PD initiated from peripheral, rather than central site. It will provide a scientific basis for the prevention and early diagnosis of PD.