Browsing by Author "Gao, Jing"

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    Data Descriptor: Daily observations of stable isotope ratios of rainfall in the tropics
    (Nature Research, 2019-10-08) Munksgaard, Niels C.; Kurita, Naoyuki; Sánchez-Murillo, Ricardo; Ahmed, Nasir; Araguas, Luis; Balachew, Dagnachew L. Balachew; Bird, Michael I.; Chakraborty, Supriyo; Chinh, Nguyen Kien; Cobb, Kim M.; Ellis, Shelby A.; Esquivel-Hernández, Germain; Ganyaglo, Samuel Y.; Gao, Jing; Gastmans, Didier; Kaseke, Kudzai F.; Kebede, Seifu; Morales, Marcelo R.; Mueller, Moritz; Poh, Seng Chee; dos Santos, Vinícius; Shaoneng, He; Wang, Lixin; Yacobaccio, Hugo; Zwart, Costijn; Earth Sciences, School of Science
    We present precipitation isotope data (δ2H and δ18O values) from 19 stations across the tropics collected from 2012 to 2017 under the Coordinated Research Project F31004 sponsored by the International Atomic Energy Agency. Rainfall samples were collected daily and analysed for stable isotopic ratios of oxygen and hydrogen by participating laboratories following a common analytical framework. We also calculated daily mean stratiform rainfall area fractions around each station over an area of 5° x 5° longitude/latitude based on TRMM/GPM satellite data. Isotope time series, along with information on rainfall amount and stratiform/convective proportions provide a valuable tool for rainfall characterisation and to improve the ability of isotope-enabled Global Circulation Models to predict variability and availability of inputs to fresh water resources across the tropics.
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    Response to correspondence on “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation”
    (BMC, 2021-04-07) Gurumurthy, Channabasavaiah B.; O’Brien, Aidan R.; Quadros, Rolen M.; Adams, John, Jr.; Alcaide, Pilar; Ayabe, Shinya; Ballard, Johnathan; Batra, Surinder K.; Beauchamp, Marie-Claude; Becker, Kathleen A.; Bernas, Guillaume; Brough, David; Carrillo-Salinas, Francisco; Chan, Wesley; Chen, Hanying; Dawson, Ruby; DeMambro, Victoria; D’Hont, Jinke; Dibb, Katharine; Eudy, James D.; Gan, Lin; Gao, Jing; Gonzales, Amy; Guntur, Anyonya; Guo, Huiping; Harms, Donald W.; Harrington, Anne; Hentges, Kathryn E.; Humphreys, Neil; Imai, Shiho; Ishii, Hideshi; Iwama, Mizuho; Jonasch, Eric; Karolak, Michelle; Keavney, Bernard; Khin, Nay-Chi; Konno, Masamitsu; Kotani, Yuko; Kunihiro, Yayoi; Lakshmanan, Imayavaramban; Larochelle, Catherine; Lawrence, Catherine B.; Li, Lin; Lindner, Volkhard; Liu, Xian-De; Lopez-Castejon, Gloria; Loudon, Andrew; Lowe, Jenna; Jerome-Majeweska, Loydie; Matsusaka, Taiji; Miura, Hiromi; Miyasaka, Yoshiki; Morpurgo, Benjamin; Moty, Katherine; Nabeshima, Yo-ichi; Nakade, Koji; Nakashiba, Toshiaki; Nakashima, Kenichi; Obata, Yuichi; Ogiwara, Sanae; Ouellet, Mariette; Oxburgh, Leif; Piltz, Sandra; Pinz, Ilka; Ponnusamy, Moorthy P.; Ray, David; Redder, Ronald J.; Rosen, Clifford J.; Ross, Nikki; Ruhe, Mark T.; Ryzhova, Larisa; Salvador, Ane M.; Shameen Alam, Sabrina; Sedlacek, Radislav; Sharma, Karan; Smith, Chad; Staes, Katrien; Starrs, Lora; Sugiyama, Fumihiro; Takahashi, Satoru; Tanaka, Tomohiro; Trafford, Andrew; Uno, Yoshihiro; Vanhoutte, Leen; Vanrockeghem, Frederique; Willis, Brandon J.; Wright, Christian S.; Yamauchi, Yuko; Yi, Xin; Yoshimi, Kazuto; Zhang, Xuesong; Zhang, Yu; Ohtsuka, Masato; Das, Satyabrata; Garry, Daniel J.; Hochepied, Tino; Thomas, Paul; Parker-Thornburg, Jan; Adamson, Antony D.; Yoshiki, Atsushi; Schmouth, Jean-Francois; Golovko, Andrei; Thompson, William R.; Lloyd, K.C. Kent; Wood, Joshua A.; Cowan, Mitra; Mashimo, Tomoji; Mizuno, Seiya; Zhu, Hao; Kasparek, Petr; Liaw, Lucy; Miano, Joseph M.; Burgio, Gaetan; Medicine, School of Medicine
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    SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1
    (Elsevier, 2021) Zhu, Chaoyu; Huang, Menghao; Kim, Hyeong-Geug; Chowdhury, Kushan; Gao, Jing; Liu, Sheng; Wan, Jun; Wei, Li; Dong, X. Charlie; Biochemistry and Molecular Biology, School of Medicine
    Fatty liver disease is the most prevalent chronic liver disorder, which is manifested by hepatic triglyceride elevation, inflammation, and fibrosis. Sirtuin 6 (Sirt6), an NAD+-dependent deacetylase, has been implicated in hepatic glucose and lipid metabolism; however, the underlying mechanisms are incompletely understood. The aim of this study was to identify and characterize novel players and mechanisms that are responsible for the Sirt6-mediated metabolic regulation in the liver. We generated and characterized Sirt6 liver-specific knockout mice regarding its role in the development of fatty liver disease. We used cell models to validate the molecular alterations observed in the animal models. Biochemical and molecular biological approaches were used to illustrate protein-protein interactions and gene regulation. Our data show that Sirt6 liver-specific knockout mice develop more severe fatty liver disease than wild-type mice do on a Western diet. Hepatic Sirt6 deficiency leads to elevated levels and transcriptional activities of carbohydrate response element binding protein (ChREBP) and sterol regulatory element binding protein 1 (SREBP1). Mechanistically, our data reveal protein-protein interactions between Sirt6 and liver X receptor α (LXRα), ChREBP, or SREBP1c in hepatocytes. Moreover, Sirt6 suppresses transcriptional activities of LXRα, ChREBP, and SREBP1c through direct deacetylation. In conclusion, this work has identified a key mechanism that is responsible for the salutary function of Sirt6 in the inhibition of hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1.