Browsing by Author "Cote, Michele"

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    A Review of Research on Disparities in the Care of Black and White Patients With Cancer in Detroit
    (Frontiers Media, 2021-07-07) Simon, Michael S.; Raychaudhuri, Sreejata; Hamel, Lauren M.; Penner, Louis A.; Schwartz, Kendra L.; Harper, Felicity W. K.; Thompson, Hayley S.; Booza, Jason C.; Cote, Michele; Schwartz, Ann G.; Eggly, Susan; Epidemiology, Richard M. Fairbanks School of Public Health
    Racial disparities in cancer incidence and outcomes are well-documented in the US, with Black people having higher incidence rates and worse outcomes than White people. In this review, we present a summary of almost 30 years of research conducted by investigators at the Karmanos Cancer Institute's (KCI's) Population Studies and Disparities Research (PSDR) Program focusing on Black-White disparities in cancer incidence, care, and outcomes. The studies in the review focus on individuals diagnosed with cancer from the Detroit Metropolitan area, but also includes individuals included in national databases. Using an organizational framework of three generations of studies on racial disparities, this review describes racial disparities by primary cancer site, disparities associated with the presence or absence of comorbid medical conditions, disparities in treatment, and disparities in physician-patient communication, all of which contribute to poorer outcomes for Black cancer patients. While socio-demographic and clinical differences account for some of the noted disparities, further work is needed to unravel the influence of systemic effects of racism against Black people, which is argued to be the major contributor to disparate outcomes between Black and White patients with cancer. This review highlights evidence-based strategies that have the potential to help mitigate disparities, improve care for vulnerable populations, and build an equitable healthcare system. Lessons learned can also inform a more equitable response to other health conditions and crises.
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    Peptide ancestry informative markers in uterine neoplasms from women of European, African, and Asian ancestry
    (Elsevier, 2021-12-23) Bateman, Nicholas W.; Tarney, Christopher M.; Abulez, Tamara S.; Hood, Brian L.; Conrads, Kelly A.; Zhou, Ming; Soltis, Anthony R.; Teng, Pang-Ning; Jackson, Amanda; Tian, Chunqiao; Dalgard, Clifton L.; Wilkerson, Matthew D.; Kessler, Michael D.; Goecker, Zachary; Loffredo, Jeremy; Shriver, Craig D.; Hu, Hai; Cote, Michele; Parker, Glendon J.; Segars, James; Al-Hendy, Ayman; Risinger, John I.; Phippen, Neil T.; Casablanca, Yovanni; Darcy, Kathleen M.; Maxwell, G. Larry; Conrads, Thomas P.; O'Connor, Timothy D.; Medicine, School of Medicine
    Characterization of ancestry-linked peptide variants in disease-relevant patient tissues represents a foundational step to connect patient ancestry with disease pathogenesis. Nonsynonymous single-nucleotide polymorphisms encoding missense substitutions within tryptic peptides exhibiting high allele frequencies in European, African, and East Asian populations, termed peptide ancestry informative markers (pAIMs), were prioritized from 1000 genomes. In silico analysis identified that as few as 20 pAIMs can determine ancestry proportions similarly to >260K SNPs (R2 = 0.99). Multiplexed proteomic analysis of >100 human endometrial cancer cell lines and uterine leiomyoma tissues combined resulted in the quantitation of 62 pAIMs that correlate with patient race and genotype-confirmed ancestry. Candidates include a D451E substitution in GC vitamin D-binding protein previously associated with altered vitamin D levels in African and European populations. pAIMs will support generalized proteoancestry assessment as well as efforts investigating the impact of ancestry on the human proteome and how this relates to the pathogenesis of uterine neoplasms.