Sheth, Aditya S.Chan, Ka-KuiLiu, ShengWan, JunAngus, Steve P.Rhodes, Steven D.Mitchell, Dana K.Davis, ChristopherRidinger, MayaCroucher, Peter J.Zeidan, Amer M.Wijeratne, ArunaQian, ShaominTran, Ngoc TungSierra Potchanant, Elizabeth A.2025-05-132025-05-132025Sheth AS, Chan KK, Liu S, et al. PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway-Deficient Acute Myeloid Leukemia. Cancer Res Commun. 2025;5(4):648-667. doi:10.1158/2767-9764.CRC-24-0260https://hdl.handle.net/1805/48028This work demonstrates that FA pathway mutations, which are frequently observed in sporadic AML, induce hypersensitivity to PLK1 inhibition, providing rationale for a novel synthetic lethal therapeutic strategy for this patient population.en-USAttribution 4.0 InternationalCell cycle proteinsProtein serine-threonine kinasesProto-oncogene proteinsFanconi anemiaArticle