Dietz, Matthew S.Beach, Catherine Z.Barajas, RamonParappilly, Michael S.Sengupta, Sidharth K.Baird, Lissa C.Ciporen, Jeremy N.Han, Seunggu J.Loret de Mola, RebeccaCho, Yoon JaeNazemi, Kellie J.McClelland, Shearwood, IIIWong, Melissa H.Jaboin, Jerry J.2020-06-092020-06-092020-01-28Dietz, M. S., Beach, C. Z., Barajas, R., Parappilly, M. S., Sengupta, S. K., Baird, L. C., Ciporen, J. N., Han, S. J., Loret de Mola, R., Cho, Y. J., Nazemi, K. J., McClelland, S., 3rd, Wong, M. H., & Jaboin, J. J. (2020). Measure Twice: Promise of Liquid Biopsy in Pediatric High-Grade Gliomas. Advances in radiation oncology, 5(2), 152–162. https://doi.org/10.1016/j.adro.2019.12.008https://hdl.handle.net/1805/22921Purpose To review and critique the current state of liquid biopsy in pHGG. Materials and Methods Published literature was reviewed for articles related to liquid biopsy in pediatric glioma and adult glioma with a focus on high-grade gliomas. Results This review discusses the current state of liquid biomarkers of pHGG and their potential applications for liquid biopsy development. Conclusions While nascent, the progress toward identifying circulating analytes of pHGG primes the field of neuro-oncoogy for liquid biopsy development.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalLiquid biopsyPediatric high-grade gliomaspHGGProtein biomarkersCell-free DNAArticle