Jaydev, FnuKumar, VinodKhatri, JaikumarShahani, ShobhaBeganovic, Sead2023-04-282023-04-282022-01-29Jaydev F, Kumar V, Khatri J, Shahani S, Beganovic S. A Case of Autoimmune Hemolytic Anemia after the First Dose of COVID-19 mRNA-1273 Vaccine with Undetected Pernicious Anemia. Case Rep Hematol. 2022;2022:2036460. Published 2022 Jan 29. doi:10.1155/2022/2036460https://hdl.handle.net/1805/32682By this time, multiple vaccines have been approved to limit the spread of SARS-CoV-2 worldwide. These include new-generation vaccines that contain mRNA of the target organism. Some common side effects were identified and reported during phase 3 clinical trials of vaccination, but more rare adverse events were reported in the literature. One such concern is autoimmune conditions that SARS-CoV-2 viral antigens could have possibly incited. We are presenting here a case of a young female with no known autoimmune diseases, diagnosed with autoimmune hemolytic anemia about a week after receiving her first dose of the COVID-19 mRNA vaccine. We discuss the possible culprit for precipitation of autoimmune hemolytic anemia after the SARS-CoV-2 mRNA vaccine, which encodes virus spike protein. This case highlights the importance of being vigilant for identifying rare adverse events that could appear during mass vaccination.en-USAttribution 4.0 InternationalVaccinesSARS-CoV-2mRNASide effectsAutoimmune conditionsViral antigensArticle