Goulart, Isabela Maria BernardesSantana, Marcela Araujo de OliveiraCosta, Willian Vargas Tenório daPavelka, Matthew MartinDornelas, Bruno de Carvalho2023-04-262023-04-262022-01-06Goulart IMB, Santana MAO, Costa WVTD, Pavelka MM, Dornelas BC. Type 2 leprosy reaction presenting as a monoarthritis post multidrug therapy. IDCases. 2022;27:e01386. Published 2022 Jan 6. doi:10.1016/j.idcr.2022.e01386https://hdl.handle.net/1805/32603Type 2 leprosy reaction, or erythema nodosum leprosum (ENL), involves a complex interaction between the host's immune system and Mycobacterium leprae. It may occur before, during, or after treatment and have a variable clinical presentation involving different body systems, such as skin, osteoarticular, kidneys, and others. Thus, the differential diagnosis, depending on its clinical presentation, can be broad and challenging. The authors report a case of a severe monoarthritis during a type 2 reaction after the multidrug therapy (MDT) was discharged and the investigation of the differential diagnoses.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalLeprosyMycobacterium lepraeErythema nodosumArthritisArticle