Maatman, Thomas K.Ceppa, Eugene P.Fogel, Evan L.Easler, Jeffrey J.Gromski, Mark A.House, Michael G.Nakeeb, AttilaSchmidt, C. MaxSherman, StuartZyromski, Nicholas J.2021-03-112021-03-112020-10Maatman, T., Ceppa, E., Fogel, E., Easler, J., Gromski, M., House, M., Nakeeb, A., Schmidt, C., Sherman, S., & Zyromski, N. (2020). Biliary Stricture after Necrotizing Pancreatitis: An Underappreciated Challenge. Annals of Surgery. https://doi.org/10.1097/SLA.0000000000004470https://hdl.handle.net/1805/25360Objective: Biliary stricture in necrotizing pancreatitis (NP) has not been systematically categorized; therefore, we sought to define the incidence and natural history of biliary stricture caused by NP. Summary/Background Data: Benign biliary stricture occurs secondary to bile duct injury, anastomotic narrowing, or chronic inflammation and fibrosis. The profound loco-regional inflammatory response of NP creates challenging biliary strictures. Methods: NP patients treated between 2005–2019 were reviewed. Biliary stricture was identified on cholangiography as narrowing of the extrahepatic biliary tree to < 75% of the diameter of the unaffected duct. Biliary stricture risk factors and outcomes were evaluated. Results: Among 743 NP patients, 64 died, 13 were lost to follow up; therefore, a total of 666 patients were included in the final cohort. Biliary stricture developed in 108 (16%) patients. Mean follow up was 3.5 ± 3.3 years. Median time from NP onset to biliary stricture diagnosis was 4.2 months (IQR, 1.8–10.9). Presentation was commonly clinical or biochemical jaundice, n = 30 (28%) each. Risk factors for stricture development were splanchnic vein thrombosis and pancreatic head parenchymal necrosis. Median time to stricture resolution was 6.0 months after onset (2.8–9.8). A mean of 3.3 ± 2.3 procedures were performed. Surgical intervention was required in 22 (20%) patients. Endoscopic treatment failed in 17% (17/99) of patients and was not associated with stricture length. Operative treatment of biliary stricture was more likely in patients with infected necrosis or NP disease duration ≥6 months. Conclusion: Biliary stricture occurs frequently after necrotizing pancreatitis and is associated with splanchnic vein thrombosis and pancreatic head necrosis. Surgical correction was performed in 20%.enPublisher Policypancreatitisacute necrotizingbenign bile duct structureArticle