Guo, ShunhuaKapp, Meghan E.Beltran, Diego M.Cardona, Cesar Y.Caster, Dawn J.Reichel, Ronald R.Fogo, Agnes B.2023-09-012023-09-012021Guo S, Kapp ME, Beltran DM, et al. Spectrum of Kidney Diseases in Patients With Hepatitis C Virus Infection. Am J Clin Pathol. 2021;156(3):399-408. doi:10.1093/ajcp/aqaa238https://hdl.handle.net/1805/35305Objectives: To study the pathologic spectrum of kidney diseases in patients with hepatitis C virus infection (HCV+). Methods: Native kidney biopsy specimens in HCV+ patients were reviewed. Results: A total of 9,836 native kidney biopsy specimens were evaluated from January 2007 to December 2016, of which 273 (2.8%) were from HCV+ patients, and of these, 115 (42.1%) had diagnoses consistent with HCV-associated glomerulonephritis (GN). Non-HCV-associated kidney diseases comprised most diagnoses (158 cases, 57.9%) including non-immune complex-mediated kidney diseases (127 cases, 46.5%) and other immune complex-mediated glomerular diseases (31 cases, 11.4%). Forty-one (40.6%) patients had HCV-associated GN among 101 HCV+ patients from 2007 to 2011 vs 74 (43.0%) patients with HCV-associated GN among 172 HCV+ patients from 2012 to 2016. HCV-associated GN showed five morphologic patterns: focal proliferative (5.2%), diffuse mesangial proliferative (50.4%), diffuse membranoproliferative (28.7%), proliferative GN with crescentic lesions (7.8%), and membranous patterns (7.8%). Conclusions: We found a spectrum of pathologic changes in renal biopsy specimens of HCV+ patients, with most having diseases unrelated to HCV infection, HCV-associated GN showing five morphologic patterns, and availability of effective HCV antiviral therapy not yet resulting in major changes in the spectrum of kidney diseases in these patients.en-USPublisher PolicyCryoglobulinemiaHCV-associated glomerulonephritisHepatitis C virus (HCV)Kidney diseaseArticle