Aguillon, DavidLangella, StephanieChen, YinghuaSanchez, JustinSu, YiVila-Castelar, ClaraVasquez, DanielZetterberg, HenrikHansson, OskarDage, Jeffrey L.Janelidze, ShorenaChen, KeweiFox-Fuller, Joshua T.Aduen, PaulaMartinez, Jairo E.Garcia, GloriaBaena, AnaGuzman, ClaudiaJohnson, KeithSperling, Reisa A.Blennow, KajReiman, Eric M.Lopera, FranciscoQuiroz, Yakeel T.2024-09-092024-09-092023Aguillon D, Langella S, Chen Y, et al. Plasma p-tau217 predicts in vivo brain pathology and cognition in autosomal dominant Alzheimer's disease. Alzheimers Dement. 2023;19(6):2585-2594. doi:10.1002/alz.12906https://hdl.handle.net/1805/43205Introduction: Plasma-measured tau phosphorylated at threonine 217 (p-tau217) is a potential non-invasive biomarker of Alzheimer's disease (AD). We investigated whether plasma p-tau217 predicts subsequent cognition and positron emission tomography (PET) markers of pathology in autosomal dominant AD. Methods: We analyzed baseline levels of plasma p-tau217 and its associations with amyloid PET, tau PET, and word list delayed recall measured 7.61 years later in non-demented age- and education-matched presenilin-1 E280A carriers (n = 24) and non-carrier (n = 20) family members. Results: Carriers had higher plasma p-tau217 levels than non-carriers. Baseline plasma p-tau217 was associated with subsequent amyloid and tau PET pathology levels and cognitive function. Discussion: Our findings suggest that plasma p-tau217 predicts subsequent brain pathological burden and memory performance in presenilin-1 E280A carriers. These results provide support for plasma p-tau217 as a minimally invasive diagnostic and prognostic biomarker for AD, with potential utility in clinical practice and trials. Highlights: Non-demented presenilin-1 E280A carriers have higher plasma tau phosphorylated at threonine 217 (p-tau217) than do age-matched non-carriers. Higher baseline p-tau217 is associated with greater future amyloid positron emission tomography (PET) pathology burden. Higher baseline p-tau217 is associated with greater future tau PET pathology burden. Higher baseline p-tau217 is associated with worse future memory performance.en-USPublisher PolicyAutosomal dominant Alzheimer's diseaseBlood biomarkersDementiaPresenilin-1Tau pathologyArticle